TABLE 4.

Generalised additive model fitted to assess the association of being admitted to the intensive care unit (ICU) with 28-day fatality ratio

	OR (95% CI)	Estimated marginal mean (range)	p-value
ICU admission	0.70 (0.65–0.75)		<0.0001
High-flow nasal cannula	1.05 (1.00–1.11)		0.052
Noninvasive respiratory support	1.37 (1.31–1.44)		<0.0001
Invasive mechanical ventilation	1.97 (1.81–2.14)		<0.0001
Vasopressors or inotropes	1.56 (1.44–1.70)		<0.0001
Number of comorbidities	1.07 (1.06–1.09)		<0.0001
Temperature on hospital admission	0.92 (0.90–0.94)		<0.0001
Heart rate on hospital admission	1.01 (1.00–1.01)		<0.0001
Respiratory rate on hospital admission	1.03 (1.02–1.03)		<0.0001
Systolic blood pressure on hospital admission	1.00 (1.00–1.01)		<0.0001
Diastolic blood pressure on hospital admission	0.99 (0.99–0.99)		<0.0001
Acute respiratory distress syndrome	1.47 (1.39–1.56)		<0.0001
Male	1.25 (1.19–1.31)		<0.0001
Month of hospital admission	0.98 (0.96–0.99)		<0.0001
New cases per million	1.00 (1.00–1.00)		<0.0001
Age (years)
20		7.1% (5.8–8.7%)
40		9.1% (8.3–9.9%)
60		19.8% (19.0–20.6%)
80		51.8% (50.7–52.9%)