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[Preprint]. 2021 Dec 5:2021.12.02.21267182. [Version 1] doi: 10.1101/2021.12.02.21267182

Table 2:

Crude and adjusted hazard ratios and 95% confidence intervals SARS-CoV-2 vaccination breakthrough infections

HR 95% CI aHR 95% CI
Among PWH and PWoH (N=109,599) a
HIV status
 PWoH 1.00 -- 1.00 --
 PWH 1.43 1.30, 1.58 1.41 1.28, 1.56
Among PWH (N=25,478) b
Sex
 Male 1.00 1.00
 Female 0.98 0.70, 1.37 0.96 0.67, 1.36
Ethnicity and Race
 Non-Hispanic white 1.00 1.00
 Non-Hispanic Black/African 1.08 0.89, 1.31 1.04 0.85, 1.27
American
 Hispanic 1.32 1.02, 1.70 1.05 0.81, 1.37
 Non-Hispanic Asian 1.32 0.84, 2.07 1.02 0.64, 1.62
 Other 0.98 0.59, 1.63 0.91 0.55, 1.52
 Unknown 1.31 0.58, 2.95 1.01 0.44, 2.29
Age (years)
 18–24 3.21 1.31, 7.86 2.94 1.19, 7.24
 25–34 1.09 0.74, 1.60 0.98 0.66, 1.46
 35–44 1.06 0.79, 1.42 1.00 0.74, 1.34
 45–54 1.00 1.00
 55–64 0.73 0.58, 0.93 0.76 0.60, 0.96
 65–74 0.63 0.49, 0.81 0.73 0.56, 0.95
 75+ 0.63 0.44, 0.91 0.76 0.52, 1.11
Primary vaccination series type
 Moderna 0.61 0.51, 0.74 0.61 0.51, 0.74
 Pfizer 1.00 1.00
 J&J 1.56 1.17, 2.09 1.35 1.01, 1.82
COVID-19 prior to fully vaccinated
 No 1.00 1.00
 Yes 3.08 2.49, 3.83 2.87 2.30, 3.56
Calendar period
 Jan – March 1.57 0.92, 2.69 1.68 0.99, 2.88
 April – June 1.00 1.00
 July – Sept 3.22 2.34, 4.44 2.92 2.12, 4.03
HIV RNA
 Unsuppressed (≥50 copies/mL) 1.00 1.00
 Suppressed (<50 copies/mL) 0.97 0.75, 1.26 1.04 0.80, 1.35
CD4 count at fully vaccinated (cells/mm3)
 <200 1.00 1.00
 200–349 1.03 0.71, 1.50 1.02 0.70, 1.48
 350–499 0.84 0.59, 1.19 0.83 0.59, 1.19
 ≥500 0.79 0.59, 1.07 0.74 0.54, 1.01

Abbreviations: HR=crude hazard ratio. aHR=adjusted hazard ratio. 95% CI=95% confidence interval.

a

Adjusted for age, sex, race and ethnicity, primary vaccination series type, COVID-19 prior to fully vaccinated, 3-month calendar period, an interaction of COVID-19 prior to fully vaccinated and 3-month calendar period, and cohort.

b

N=6,362 (20% of all PWH) were excluded due to missing CD4 or HIV RNA measurements. Adjusted for the covariates in the table and cohort.