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. 2021 Nov 30;12:726784. doi: 10.3389/fphar.2021.726784

TABLE 4.

Association of SNP genotypes with tacrolimus C₀/D.

	6th day			6 months			1 year
Gene/genotype	n	C₀/D	p value	n	C₀/D	p value	n	C₀/D	p value
CYP3A5*3
3/3	50	145.45 ± 54.99	<0.001 ^a	43	163.06 ± 74.29	<0.001 ^a	32	176.1 ± 64.65	<0.001 ^a
1/3	33	77.1 ± 38.43		38	107.38 ± 50.61		28	114.07 ± 57.21
1/1	9	66.46 ± 36.09		8	87.18 ± 53.18		6	62.38 ± 33.75
CYP3A5 Non-expressor	50	145.45 ± 54.99	<0.001 ^a	43	163.06 ± 74.29	<0.001 ^a	32	176.1 ± 64.65	<0.001 ^a
CYP3A5 Expressor	42	74.82 ± 37.77	<0.001 ^a	46	103.87 ± 51.04	<0.001 ^a	28	104.95 ± 57.01	<0.001 ^a
CYP3A4*1G
1/1	39	146.11 ± 58.02	<0.001 ^a	33	168.89 ± 72.7	<0.001 ^a	26	180.48 ± 63.39	<0.001 ^a
1/1G	38	92.65 ± 49.31		41	109.5 ± 58.99		31	121.37 ± 60.75
1G/1G	13	72.02 ± 38.72		13	108.25 ± 55.88		8	66.21 ± 29.39
CYP3A4*1B
AA	80	117.36 ± 60.12	0.048 ^a	81	132.12 ± 71.19	0.972	63	137.28 ± 70.85	0.472
AG	9	75.87 ± 44.56	0.048 ^a	5	133.26 ± 55.7	0.972	1	189	0.472
ABCB1 C3435T
CC	10	142.57 ± 71.69	0.193	12	125.08 ± 79.03	0.73	11	106.66 ± 56.38	0.216
CT	38	115.5 ± 54.5		33	140.33 ± 72.36		23	151.03 ± 69.46
TT	43	104.97 ± 60.14		43	129.2 ± 66.65		32	142.39 ± 73.43
ABCB1 G2677T
GG	8	147.86 ± 71.44	0.219	10	149.08 ± 75.37	0.706	8	133.32 ± 60.61	0.727
GT	42	107.75 ± 55.52		35	127.95 ± 74.06		28	146.16 ± 72.68
TT	39	111.87 ± 61.19		41	131.69 ± 66.48		28	131.38 ± 72.58

^a

Statistically significant.