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. 2021 Nov 30;9:759154. doi: 10.3389/fcell.2021.759154

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Copyright © 2021 Zhang, Hao, Guo, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristic of TP53 mutation in TCGA-BRAC patients. Overall information of somatic mutation of BRCA patients (A); the top 30 significant mutations were found in the TCGA-BRCA cohort, of which the left side was TP53-mutant group and the right side was TP53-wt group (B); the distribution of the top 30 significant mutations in the dataset of BRCA-FR (C) and BRCA- KR (D); the distribution of amino acids in TP53 protein in TCGA-BRCA, BRCA-FR, and BRCA-KR data sets (E); the results of CNV for TCGA-BRCA were visualized by MAFtools (F). SNP, single nucleotide polymorphism; SNV, single nucleotide variant; CNV, copy number variation.