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. 2021 Nov 30;9:759154. doi: 10.3389/fcell.2021.759154

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Copyright © 2021 Zhang, Hao, Guo, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The drug sensitivity caused by TP53 mutation. The relationship between gene mutation level and different kinds of drugs in TCGA-BRCA dataset was analyzed (A); analysis of gene mutation level in different carcinogenic signaling pathways in TCGA-BRCA dataset (B); mutation distribution of six major genes in TP53 signaling pathway in TCGA-BRCA patients (C); the volcano map shows the sensitivity analysis of TP53 gene mutation to different anticancer chemotherapy drugs; the red circle indicates that TP53 gene mutation leads to the decrease of drug sensitivity (D); compared with TP53-wt group, the IC50 value of nutlin-3a (-) in patients with TP53 mutation was significantly higher (E). wt, wild type.