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. 2021 Nov 30;9:759154. doi: 10.3389/fcell.2021.759154

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Copyright © 2021 Zhang, Hao, Guo, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between TP53 mutation and immunological phenotype in TCGA-BRCA patients. In TCGA-BRCA dataset, the ImmuneScore and StromalScore of TP53-mutant patients were significantly increased (A); there was significant difference in the expression of HLA family genes between the two groups (B); the histogram showed the proportion of 22 different immune cells in TCGA-BRCA patients (C); the results of the difference analysis showed that the infiltration level of various immune cells was significantly different in TP53-mutant and TP53-wt group (D).