FIG. 5.

Mammary gland architecture of MMTV/activated neu mutants. Photoimages show whole-mount preparations (A, C, and E) and comparable microscopic fields (B, D, and F) of mammary glands of mice harboring NYPD10 (A and B), YD5 (C and D), and YB2 (E and F) neu autophosphorylation mutants. All mammary glands are from 12 to 14-week-old virgin female mice. Note that all mammary whole mounts have some degree of alveolar development and foci of intraluminal hyperplasia. The YB mutant mice had the most severe ductal ectasia with scattered foci of papillary hyperplasia (E and F). The YD mutant strain had less ductal ectasia, but the hyperplastic lesions were composed of solid glandular arrays (C and D). The NYPD mutant had significant lobular development that tended to follow normal histological patterns (A and B). (Normal mammary gland morphologies for the FVB strain can be viewed online [http://ccm.ucdavis.edu/tgmouse/wmtable.htm].) The size bars in panels E and F indicate 1 and 0.1 mm, respectively.