FIGURE 4.

(A) Conditioned place preference (CPP) % formed by saline-treated and methamphetamine (meth)-treated mice at baseline and test (n = 18–24 per group). Percent preference was calculated by dividing time spent in the afternoon chamber by the combined time spent in both chambers. Columns show mean (±SEM). Effect of Day only in meth group: (&) p < 0.05. (B) CPP % change at test normalized to baseline in meth-treated mice only [i.e., CPP % change = (% at test–% at baseline)/% at baseline]. Effect of Age: (*) p < 0.05. (C) Based on normalized CPP % change, proportion of mice that formed a preference (CPP % change > 10%), remained neutral (CPP % change between 10% and −10%), and formed an aversion (CPP % change < −10%) to the meth (0.1 mg/kg)-paired chamber at test. Effect of Sex: (#) p < 0.05.