TABLE 1.
Case-Series and Case Reports of Vaccine-Induced Immune Thrombotic Thrombocytopenia
| S. No. | References | Date Published | No. of Cases (Female/Male) | Site of Thrombus | Key Findings |
|---|---|---|---|---|---|
| 1 | Muir et al (4) | April 14, 2021 | 1 (1/0) | Splanchnic vein | The patient showed severe thrombocytopenia (13,000/mm3) with schistocytes, low fibrinogenemia, and DIC. |
| 2 | Greinacher et al (5) | April 9, 2021 | 11 (9/2) | CVT: 9, splanchnic vein: 3, PE: 3, other: 4 | Five cases had DIC and one presented fatal intracranial hemorrhage. |
| 3 | Schultz et al (6) | April 9, 2021 | 5 (4/1) | Cerebral vein: 4, splanchnic vein: 1 | Four cases had major cerebral hemorrhage. Platelet counts increased in all cases despite of the treatment with low-molecular-weight heparin. |
| 4 | Scully et al (7) | April 16, 2021 | 23 (14/9) | CVT: 13, PE: 4, splanchnic vein: 2, etc. | Secondary cerebral hemorrhage was recognized in some cases after CVT. Two cases had ischemic stroke. Seven (30%) died. |
| 5 | Sadoff et al (8) | April 16, 2021 | 1 (0/1) | CVT | Single case of CVT with thrombocytopenia occurred in a vaccine recipient during the clinical trial program for the Ad26.COV2.S vaccine (of which ∽50,000 received active vaccine). |
| 6 | Franchini et al (9) | April 12, 2021 | 1 (0/1) | CVT | CVT with multiple parenchymal hemorrhage. |
| 7 | Mehta et al (10) | April 20, 2021 | 2 (0/2) | CVT | Both two were males. |
| 8 | Thaler et al (11) | April 20, 2021 | 1 (1/0) | None | Petechiae and hematomas were the only symptoms. |
CVT = cerebral venous thrombosis, DIC = disseminated intravascular coagulation, PE = pulmonary embolism.