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. 2021 Nov 30;9:718974. doi: 10.3389/fcell.2021.718974

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Copyright © 2021 Wang, Li, Ming, Wei, Du, Zhou, Zong and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical characteristics and overall survival among different subgroups of HNSCC. *, **, *** represent p < 0.05, p < 0.01 and p < 0.0001, respectively. (A) Consensus matrix for optimal k = 2. (B) Principal component analysis (PCA) of cluster 1 and cluster 2. (C) Kaplan-Meier curve of overall survival (OS) time in Cluster 1 and Cluster 2 (p = 0.03). (D) Heatmap of the clinical features of the two clusters. (E) GSEA analysis displayed key pathways in in Cluster 1 and Cluster 2. (F) The violet plot showed the differential expression of immune cells between Cluster 1 and Cluster 2, in which Cluster 1 was represented in blue and Cluster 2 was represented in red. (G) The heatmap of the differential expression levels of 29 immune checkpoint genes between Cluster 1 and Cluster 2. (H) The boxplot of TP53 expression level between Cluster 1 and Cluster 2.