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. 2021 Nov 30;9:718974. doi: 10.3389/fcell.2021.718974

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Copyright © 2021 Wang, Li, Ming, Wei, Du, Zhou, Zong and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of differential TMB level on patients’ prognosis and TP53 somatic mutation. (A) Comparison of prognosis between high TMB subgroup and low TMB subgroup. (B) Comparison of prognosis of TMB combined with risk score. (C,D) Top 20 genes with the most significant mutation rates in high-risk subgroup and low-risk subgroup. (E) The differential expression level TP53 between high-risk group and low-risk group. (F) Kaplan–Meier curve analysis of overall survival was shown for patients classified according to TP53 mutation status and risk score. TP53-wt: wild type of TP53 sequence; TP53-mt: mutation type of TP53 sequence.