TABLE 1.
Clinical presentation of celiac disease in relation to the two considered periods
| P1 (1990–2011) n = 517 n (%) |
P2 (2012–2020) n = 564 n (%) |
p value | Total 1081 n (%) |
|
|---|---|---|---|---|
| Symptoms | ||||
| GASTROINTESTINAL | 182 (35%) | 294(52%) | p < 0.001 | 476 (44%) |
| Diarrhea | 85 (47%) | 88 (30%) | p < 0.001 | 173 (36%) |
| Recurrent abdominal pain | 87 (48%) | 150 (51%) | p = 0.49 | 237 (50%) |
| Constipation | 8 (4%) | 57 (19%) | p < 0.001 | 65 (14%) |
| Vomit / GER | 23 (13%) | 28 (10%) | p = 0.29 | 51 (11%) |
| Stomatitis / Aftosis | 1 (1%) | 10 (3%) | P = 0.06 | 11 (2%) |
| Bloating | 2 (1%) | 36 (12%) | p < 0.001 | 38 (8%) |
| EXTRAINTESTINAL | 72 (14%) | 86(15%) | p = 0.54 | 158 (15%) |
| Anemia | 55 (76%) | 37 (43%) | p < 0.001 | 92 (58%) |
| Neurologic symptoms | 7 (10%) | 21 (24%) | p = 0.02 | 28 (18%) |
| Skin | 9 (13%) | 25 (29%) | p = 0.01 | 34 (22%) |
| Dental Enamel Defects | 1 (1%) | 6 (7%) | p = 0.13 | 7 (4%) |
| SCREENING | 199(38%) | 213(38%) | p = 0.81 | 412(38%) |
| Absence of symptoms/risk factors | 97 (49%)[19%]* | 129 (60%)[23%]* | p = 0.09 | 226 (55%)[21%]* |
| 1st degree familiarity | 58 (29%) | 57 (27%) | p = 0.61 | 115 (28%) |
| Autoimmune associated conditions | 44 (22%) | 27 (13%) | p = 0.01 | 71 (17%) |
| FAILURE TO THRIVE | 140(27%) | 121 (21%) | P = 0.03 | 261 (24%) |
| Age Groups | ||||
| G1 (< 2.0 years) | 94 (18%) | 47 (8%) | p < 0.001 | 141 (13%) |
| G2 (2.1–6.0 years) | 212 (41%) | 228 (40%) | p = 0.85 | 440 (41%) |
| G3 (6.1–12.0 years) | 163 (32%) | 238 (42%) | p < 0.001 | 401 (37%) |
| G4 (12.1–18 years) | 48 (9%) | 51 (9%) | p = 0.89 | 99 (9%) |
[]* % on the total period’s sample