Table 1.
The basic characteristics of the enrolled studies
| Author | Country | Age | Number | Surgical type | Administration | Events of POCD | MMSE score (mean ± SD) | Jadad score | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | Cases/controls | Cases/controls | 1 day after surgery | 3 days after surgery | 7 days after surgery | 1 day after surgery | 3 days after surgery | 7 days after surgery | ||||
| Peng2012 | China | 70.6/67.2 | 40/40 | Prostate resection | DEX/Saline | NA | 5/11 | NA | NA | 24.3 ± 0.6/20.5 ± 0.7 | NA | 4 |
| Chen2013 | China | 66.2/67.9 | 59/63 | Laparoscopic cholecystectomy | DEX/Saline | 9/27 | NA | NA | NA | NA | 27.6 ± 1.2/25.7 ± 1.5 | 5 |
| Zhang2014 | China | 71.6/71.5 | 60/20 | Laparoscopic surgery | DEX/Saline | NA | 8/7 | 6/7 | NA | NA | NA | 4 |
| Mohamed2014 | Africa | 63.9/67.8 | 25/25 | Abdominal surgery | DEX/Saline | 4/20 | NA | NA | NA | NA | NA | 5 |
| Ding2015 | China | NA | 20/20 | Laparoscopic prostatectomy | DEX/Saline | 9/12 | NA | NA | NA | NA | NA | 5 |
| Li2015 | China | 69/70 | 50/50 | Laparoscopic cholecystectomy | DEX/Saline | 10/21 | NA | NA | 27.9 ± 1.7/26.7 ± 1.9 | NA | NA | 4 |
| Guan2015 | China | 65.9/68.2 | 30/30 | Laparoscopic surgery | DEX/Saline | 9/8 | 10/9 | NA | 23.35 ± 5.16/22.46 ± 4.35 | 27.84 ± 4.67/25.79 ± 4.90 | NA | 4 |
| Liu2015a | China | 72.84/75.25 | 39/40 | Joint replacement | DEX/Saline | 5/6 | 3/6 | 2/13 | NA | NA | NA | 5 |
| Liu2015b | China | 71.23/72.81 | 60/58 | Joint replacement | DEX/Saline | 2/9 | 3/6 | 0/3 | NA | NA | NA | 5 |
| Xu2016 | China | 51/48.8 | 40/40 | Orthotopic liver transplatation | DEX/Saline | 8/18 | NA | NA | 25.87 ± 1.93/22.41 ± 2.95 | NA | NA | 5 |
| Deiner2017 | USA | 74/74 | 189/201 | Elective non-cardiac surgery | DEX/Saline | 23/23 | NA | NA | NA | NA | NA | 5 |
| Ma2017 | China | 49.3/48.1 | 25/25 | Thyroid surgery | DEX/Saline | NA | NA | NA | 24.86 ± 2.48/22.37 ± 2.36 | 25.92 ± 2.4/23.43 ± 2.38 | NA | 4 |
| Xu2017 | China | 71.9/72.1 | 48/48 | Ovarian cystectomy | DEX/Saline | 0/2 | 1/2 | 0/0 | NA | NA | NA | 5 |
| Kong2018 | China | 67.8/68.9 | 60/60 | Cancer surgery | DEX/Saline | 6/17 | NA | NA | 27.1 ± 0.69/23.14 ± 0.71 | 28.53 ± 0.62/24.8 ± 0.55 | NA | 4 |
| Zheng2018 | China | 42.3/42.4 | 40/40 | Coronary artery bypass grafting | DEX/Saline | 1/10 | NA | NA | 20.6 ± 0.5/17.5 ± 0.9 | 25.1 ± 0.7/21.3 ± 1.1 | 28.6 ± 0.3/23.8 ± 0.7 | 4 |
| Zhang2019 | China | 73.76/74.09 | 80/60 | Radical colorectal cancer surgery | DEX/Saline | 7/13 | 0/8 | NA | 26.76 ± 1.67/24.15 ± 1.98 | 28.11 ± 2.01/26.09 ± 1.78 | NA | 4 |
| Cheng2019 | China | 71/70 | 269/266 | Gastro-intestinal laparotomy | DEX/Saline | NA | 40/65 | 31/49 | NA | NA | NA | 5 |
| Shi Haixia2020 | China | 66.4/67.6 | 40/40 | Thoracoscopic lobectomy | DEX/Saline | NA | 4/12 | NA | NA | 27.6 ± 2.3/24.1 ± 4.01 | NA | 5 |
| Shi Hai-Xia2020 | China | 68.71/68.7 | 53/53 | Thoracoscopic lobectomy | DEX/Saline | 7/19 | NA | NA | 26.3 ± 1.27/26.09 ± 1.01 | NA | NA | 4 |
| Bin2020 | China | 72/73 | 183/183 | Knee hip arthroplasty | DEX/Propofol | NA | NA | NA | NA | 24.3 ± 3.9/22.1 ± 4.3 | 25.6 ± 4.8/23.3 ± 3.3 | 5 |
| Wang2020 | China | 68.37/68.26 | 60/50 | Radical gastrectomy | DEX/Saline | 12/20 | NA | NA | 27.34 ± 2.45/24.21 ± 3.11 | NA | NA | 4 |
| Yan2020 | China | 69.5/70.4 | 30/30 | Coronary artery bypass grafting | DEX/Saline | NA | 3/9 | 0/5 | 28.4 ± 1.2/28.2 ± 1.1 | 24.5 ± 1.1/20.3 ± 1.3 | 28.2 ± 1.3/24.2 ± 1.2 | 4 |
DEX dexmedetomidine, NA not available
Liu2015a and Liu2015b are from same study