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. 2021 Dec 14;22:592. doi: 10.1186/s12859-021-04505-w

Fig. 1.

Fig. 1

Schematic diagram of gcMECM. A The mutation matrix, displaying a landscape of mutation status across genes at vertical axis and samples at horizontal axis, is used to calculate gene–gene association of mutations with Fisher’s exact test and generalized linear models (GLM). Arches are used to highlight subnetworks. B Identification of modules with graph-based clustering of negatively correlated genes. C Overlay of mutually exclusive subnetworks in the context of canonical pathways using the graph-matching algorithm