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. 2021 Dec 14;19:508. doi: 10.1186/s12967-021-03173-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TRIM38 expressed lowly in BLCA and down-regulated TRIM38 correlated with advanced clinical characteristics and poor prognosis. a Representative immunohistochemistry (IHC) graphs showing the staining levels of TRIM38 in patients with different tumor grades. scale bars = 100 μm (upper), scale bars = 20 μm (lower). b The results from qRT-PCR analysis exhibited that the TRIM38 mRNA levels were notably upregulated in BLCA samples relative to their adjacent normal tissues. β-actin was detected as the loading control. c–f Low TRIM38 expression levels correlated with tumor metastatic stages, lymph node metastasis, clinical pathological stages and TP53 mutation status. g, h Other BLCA datasets (GSE13507 and GSE32548) were utilized to suggest that patients with low TRIM38 expressions suffered from shorter overall survival (OS) probability compared with patients with high TRIM38