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. 2021 Nov 30;8:736272. doi: 10.3389/fmolb.2021.736272

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Copyright © 2021 Yang, Fang, Wu, Tian, Gao, Yu, Chen, Weng, Zhu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum protein profiles in patient cohorts in the current study. (A–C) Volcano plot exhibiting the DAPs in the T2DM, CRC and T2DM + CRC patients in comparison with healthy participants. DAPs were extracted using R language 4.0.0 with a criterion of fold change (FC) ≥ 1.50 or ≤0.67 and unpaired t-test p value ≤0.05. (D) Hierarchical cluster analysis of the 67 DAPs in the groups of healthy participants, T2DM, CRC, and T2DM + CRC. There were five samples in each group. Red represents for high expression and blue represents for low expression.