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. 2021 Nov 30;12:755401. doi: 10.3389/fimmu.2021.755401

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Copyright © 2021 Wang, Tan, Yu, Chen, Jing and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The correlation between LUAD-related ISs and immune modulators and the feature of immune cells in different ISs. (A) Differentially expressed ICP genes in different LUAD ISs. (B) Differentially expressed ICD genes in different LUAD ISs. Kruskal–Wallis test with ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.001. ns presents no difference. (C) Differential enrichment scores of immune cell signatures among five ISs in TCGA cohorts. (D) Differential enrichment scores of ten prognosis-related immune cell signatures. (E) The distribution of five pan-cancer ISs in five LUAD-related ISs. (F) Differential enrichment scores of twenty-four immune signatures.