Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 30;9:596702. doi: 10.3389/fcell.2021.596702

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Wang, Meng and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Tropoelastin secretory/assembly pathway. The synthesis of tropoelastin begins with the transcription of the ELN gene in the nucleus. In the endoplasmic reticulum, tropoelastin interacts with EBP and folds in structure. After the storage and transport of Golgi, the complex of EBP and tropoelastin is secreted to the cell surface for self-assembly. Then, tropoelastin dissociates from EBP and deposits onto the microfibril scaffold. In the presence of LOX, tropoelastin cross-links and eventually forms mature elastic fibers.