Table 2.

Multivariable analysis (Cox proportional hazard model) of OS for HR+ MBC

N = 832 (events 525)	HR	95% CI	P
Age (continuous) according to menopausal status
Premenopausal	1.04	1.03–1.06	< 0.001
Postmenopausal	1.03	1.02–1.04	< 0.001
DFS
≥ 24 months or de novo versus < 24 months	0.75	0.59–0.95	0.017
Visceral versus no visceral disease*	1.26	1.02–1.55	0.030
Number of metastatic sites*
2–3 versus 1	1.25	1.02–1.53	0.029
≥ 4 versus 1	1.73	1.16–2.59	0.007
HER2-low versus HER2-0	0.89	0.74–1.05	0.171

Statistically significant p-values are highlighted in bold

*At diagnosis of metastatic disease