Table 3.

Multivariable analysis (Cox proportional hazard model) of OS for HR-negative MBC

N = 227 (events 199)	HR	95% CI	P
Age (continuous) according to menopausal status
Premenopausal	1.04	1.01–1.06	0.004
Postmenopausal	1.02	1.01–1.04	0.002
DFS
≥ 24 months or de novo versus < 24 months	0.59	0.44–0.80	0.001
Visceral versus no visceral disease*	1.59	1.15–2.20	0.005
Number of metastatic sites*
2–3 versus 1	1.23	0.89–1.68	0.210
≥ 4 versus 1	2.01	1.17–3.48	0.012
HER2-low versus HER2-0	0.92	0.68–1.25	0.585

Statistically significant p-values are highlighted in bold

*At diagnosis of metastatic disease