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. 2021 Nov 18;8(12):2235–2251. doi: 10.1002/acn3.51473

Table 6.

Test re‐test reproducibility of pRNFL OCT measurements.

MS group Reference group

All patients with MS

N = 656

Patients without MS‐ON1 N = 537 Patients with MS‐ON N = 119

Healthy participants

N = 122

n 642 524 118 121
Baseline, (µm) 88.84 ± 15.35 91.52 ± 13.89 76.86 ± 15.87 100.45 ± 9.15
Month 1, (µm) 88.96 ± 15.41 91.64 ± 14.01 77.03 ± 15.78 100.13 ± 9.34
Difference, (µm) 0.12 ± 1.82 0.14 ± 1.86 0.01 ± 1.60 −0.35 ± 1.73
95% CI for mean (−0.02, 0.26) (−0.02, 0.30) (−0.28, 0.30) (−0.66, −0.04)
p‐value 0.1036 0.0840 0.9429 0.0271
ICC (95% CI) 0.993 (0.992, 0.994) 0.991 (0.989, 0.992) 0.995 (0.993, 0.996) 0.982 (0.974, 0.987)

Values are mean ± SD unless otherwise indicated

CI, confidence interval; ICC, intraclass correlation coefficient; MS, multiple sclerosis; MS‐ON; multiple sclerosis‐associated optic neuritis; N is the total number of eyes in the analysis population, n is the number of eyes with data available.

1Without previous MS‐ON