FIGURE 4.

Sustained NO release from nitrate-functionalized SDVGs enhances the formation of an organized VSMC layer. (A) Immunohistochemical staining of SDVG enface sections (left panels, scale bar = 1 mm; right panels, scale bar = 100 µm) for α-SMA expression at 1- and 3-months post-implantation. (B) Quantification of average α-SMA⁺ neointimal thickness. (C) Immunohistochemical staining of SDVG enface sections (left panels, scale bar = 1 mm; right panels, scale bar = 100 µm) for SM-MHC expression at 1- and 3-months post-implantation. (D) Quantification of average SM-MHC⁺ neointimal layer thickness. Images and data are representative of n = 4 independent experiments. White dashed line boxes indicate zoomed area. White dashed line borders indicate the graft wall.