Table 2:
Proteins hypothesized to play a role in odorant transport and metabolism: CRSsNP versus controls.
| Protein name | Majority protein IDs | Gene name | Log2 Fold Change | p-value* | FDR |
|---|---|---|---|---|---|
| Possible odorant binding protein | |||||
| Lipocalin-15 | Q6UWW0 | LCN15 | −2.15 | 0.030 | 0.130 |
| Glutathione S transferases and synthetase | |||||
| Glutathione S-transferase Mu 2 | P28161;E9PHN7;E9PHN6;F6XZQ7;E9PLF1 | GSTM2 | −1.82 | 0.021 | 0.109 |
| Glutathione S-transferase A3 | Q16772;Q5JW85 | GSTA3 | −1.75 | 0.002 | 0.051 |
| Glutathione synthetase | P48637;A0A2R8Y430;A0A2R8Y5T7 | GSS | −0.36 | 0.017 | 0.102 |
| Alcohol/aldehyde dehydrogenases | |||||
| Alcohol dehydrogenase [NADP(+)] | P14550 | AKR1A1 | −0.52 | 0.022 | 0.110 |
| Alcohol dehydrogenase 1C | P00326 | ADH1C | −1.07 | 0.007 | 0.059 |
| Alcohol dehydrogenase class-3 | P11766 | ADH5 | −0.45 | 0.044 | 0.144 |
| Alcohol dehydrogenase class 4 mu/sigma chain | P40394;A0A0C4DG85;E9PFG0 | ADH7 | −0.95 | 0.005 | 0.054 |
| Aldehyde dehydrogenase, dimeric NADP-preferring | P30838;I3L3I9;A8MYB8;C9JMC5;E9PNN6 | ALDH3A1 | −1.02 | 0.020 | 0.108 |
| Other anti-oxidant enzymes | |||||
| Glutathione peroxidase 1 | A0A087WUQ6;P07203;A0A2R8Y6B6 | GPX1 | −0.60 | 0.003 | 0.048 |
| Glutathione peroxidase 2 | A0A087WTS0;P18283;H0YJK8 | GPX2 | −1.07 | 0.022 | 0.107 |
| Peroxiredoxin-1 | Q06830;A0A0A0MSI0 | PRDX1 | −0.68 | 0.022 | 0.104 |
| Peroxiredoxin-5 | P30044 | PRDX5 | −0.91 | 0.022 | 0.101 |
| Peroxiredoxin-6 | P30041 | PRDX6 | −0.58 | 0.043 | 0.155 |
A two-sided Student’s t test was performed comparing the mean log2 protein intensities from CRSsNP versus controls. CRSsNP, chronic rhinosinusitis without nasal polyposis
*
=unadjusted p-value; FDR=permutation-based false discovery rate.