Table 7:
GO and Reactome pathways in normosmic versus dysosmic subjects
| Cluster color from heat map | Gene Ontology and Reactome pathway | Size Intersection/Category size | p-value | FDR |
|---|---|---|---|---|
|
| ||||
|
Enriched in Dysosmic
| ||||
| Peach | Overall Number of Proteins in Cluster | 18 | 1.67E-16 | 2.51E-16 |
| Cytoplasmic translation [GO:0002181] | 7/23 | 4.97E-09 | 1.38E-05 | |
| Polysomal ribosome [GO:0042788] | 5/18 | 1.94E-06 | 0.000639 | |
| Cytosolic large ribosomal subunit [GO:0022625] | 10/37 | 2.99E-12 | 2.14E-09 | |
| Structural constituent of ribosome [GO:0003735] | 14/65 | 3.02E-16 | 2.44E-12 | |
| SRP-dependent cotranslational protein targeting to membrane [GO:0006614] | 14/67 | 4.81E-16 | 1.2E-11 | |
| Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184] | 14/76 | 3.28E-15 | 4.11E-11 | |
| Translation [GO:0006412] | 14/79 | 5.88E-15 | 4.91E-11 | |
| L13a-mediated translational silencing of Ceruloplasmin expression pathway | 14/83 | 1.23E-14 | 2.55E-11 | |
| Translational initiation [GO:0006413] | 14/90 | 4.13E-14 | 2.58E-10 | |
| Nucleolus [GO:0005730] | 7/90 | 8.44E-05 | 0.019025 | |
| Focal adhesion [GO:0005925] | 9/137 | 2.1E-05 | 0.005619 | |
| RNA binding [GO:0003723] | 14/282 | 3.85E-07 | 0.001038 | |
| Membrane [GO:0016020] | 15/323 | 1.89E-07 | 8.1E-05 | |
|
| ||||
| Light Blue | Overall Number of Proteins in Cluster | 53 | 2.11E-49 | 6.32E-49 |
| Positive regulation of cholesterol esterification [GO:0010873] | 4/5 | 1.12E-05 | 0.018638 | |
| Membrane attack complex [GO:0005579] | 5/7 | 1.68E-06 | 0.0006 | |
| Terminal pathway of complement pathway | 5/7 | 1.68E-06 | 0.001157 | |
| Complement activation, alternative pathway [GO:0006957] | 6/9 | 2.37E-07 | 0.00054 | |
| Negative regulation of endopeptidase activity [GO:0010951] | 13/26 | 1.03E-12 | 5.18E-09 | |
| Serine-type endopeptidase inhibitor activity [GO:0004867] | 14/30 | 4.07E-13 | 1.65E-09 | |
| Acute-phase response [GO:0006953] | 6/14 | 7.06E-06 | 0.012625 | |
| Platelet alpha granule lumen [GO:0031093] | 10/26 | 1.41E-08 | 8.6E-06 | |
| Blood microparticle [GO:0072562] | 31/84 | 3.6E-26 | 1.54E-22 | |
| Cellular protein metabolic process [GO:0044267] | 15/48 | 5.54E-11 | 2.31E-07 | |
| Regulation of complement activation [GO:0030449] | 13/42 | 1.53E-09 | 5.47E-06 | |
| Collagen-containing extracellular matrix [GO:0062023] | 23/76 | 1.56E-16 | 1.67E-13 | |
| Platelet degranulation [GO:0002576] | 13/43 | 2.12E-09 | 6.65E-06 | |
| Platelet degranulation pathway | 13/48 | 9.55E-09 | 9.86E-06 | |
| Endoplasmic reticulum lumen [GO:0005788] | 12/48 | 1.04E-07 | 5.56E-05 | |
| Complement activation, classical pathway [GO:0006958] | 11/49 | 1.23E-06 | 0.00257 | |
| Extracellular space [GO:0005615] | 41/252 | 5.76E-21 | 8.22E-18 | |
| Extracellular region [GO:0005576] | 45/307 | 3.04E-22 | 6.51E-19 | |
|
| ||||
|
Decreased in Dysosmic
| ||||
| Dark Pink | Overall Number of Proteins in Cluster | 20 | 2.67E-18 | 5.33E-18 |
| Epidermis development [GO:0008544] | 4/9 | 4.55E-06 | 0.00876 | |
|
| ||||
| Black | Overall Number of Proteins in Cluster | 86 | 8.53E-84 | 5.12E-83 |
| Oxidation-reduction process [GO:0055114] | 11/23 | 3.16E-08 | 7.93E-05 | |
Enrichment of GO terms associated with protein clusters was performed using a Fisher exact test with a Benjamini-Hochberg FDR<0.02. CRSwNP, chronic rhinosinusitis with nasal polyposis;
*
=unadjusted p-value; FDR=false discovery rate.