Fig. 2.

Dose-dependent effect and desensitization characteristics of MET currents in Cho neurons. (A) Representative traces recorded from a lch1 neuron in response to 0.2-, 0.4-, 0.6-, 0.8-, 1.0-, and 1.2-μm displacements. (B) The MET currents (absolute value) increased with increased displacements. n = 6 for each displacement. The displacements were 0, 0.2, 0.4, 0.6, 0.8, 1.0, and 1.2 μm. All error bars denote ± SEM. (C and D) Representative traces of MET currents in lch1 in response to repetitive stimuli with a short (10 ms) and long (110 ms) interval. One mechanical stimulus evoked both “on” and “off” responses; arrows and asterisks represent the “on” and “off” response currents, respectively. (E) Summary of the amplitude of MET currents evoked by repetitive stimuli with different intervals ranging from 10 ms to 110 ms with 20-ms increments (mean ± SEM; n = 6 for each group). The lch1 neuron was clamped at −60 mV (holding potential) in Na⁺/K⁺-based solutions.