Table 3.
Associations between gene expression and therapy outcome in clinical studies of IC blockade.
| Gene | Cohort | Cancer | Subtype | Survival | Risk.adj |
|---|---|---|---|---|---|
| ANLN | Riaz2017_PD1 | Melanoma | Ipi_Prog | OS | 2.025 |
| Riaz2017_PD1 | Melanoma | Ipi_naive | PFS | -3.136 | |
| CFL2 | Liu2019_PD1 | Melanoma | Ipi_naive | OS | 2.489 |
| ITGA5 | Mariathasan2018_PDL1 | Bladder | mUC | OS | 3.52 |
| Miao2018_ICB | Kidney | Clear | PFS | -3.173 | |
| KIF23 | Riaz2017_PD1 | Melanoma | Ipi_Prog | OS | 2.802 |
| NFIA | Mariathasan2018_PDL1 | Bladder | mUC | OS | 2.987 |
| Zhao2019_PD1 | Glioblastoma | Pre | PFS | -2.336 | |
| PTX3 | Riaz2017_PD1 | Melanoma | Ipi_naive | OS | 2.467 |
| RELT | Mariathasan2018_PDL1 | Bladder | mUC | OS | 2.505 |
| Liu2019_PD1 | Melanoma | Ipi_naive | PFS | -2.32 | |
| TMC7 | Hugo2016_PD1 | Melanoma | OS | 2.27 | |
| Lauss2017_ACT | Melanoma | OS | -2.528 |