Skip to main content
. Author manuscript; available in PMC: 2021 Dec 14.
Published in final edited form as: Gene Ther. 2011 May 5;18(11):1098–1102. doi: 10.1038/gt.2011.61

Figure 1.

Figure 1

Optimal Timing of Radiation in Glioma Xenografts Injected with Oncolytic HSV-1 for Viral Gene Expression and Tumor Regression. HSV-1 R2636 was injected at time 0, and 20 Gy of IR was delivered before or after viral injection. 1A: Luciferase expression was quantified on days 1, 2, 3, 4, 5, and 7 after viral injection in non-irradiated and irradiated mice by measuring photon flux. The mean bioluminescence of 5 xenografts per group are shown, and normalized to values obtained in non-irradiated R2636 injected xenografts on day 1. 1B: Fractional tumor volumes of glioma xenografts imaged in Figure 1A Tumors volume measurements were normalized to tumor volumes on day 0.