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. Author manuscript; available in PMC: 2021 Dec 14.
Published in final edited form as: ACS Appl Bio Mater. 2020 Dec 30;4(1):984–994. doi: 10.1021/acsabm.0c01443

Figure 2.

Figure 2.

Dynamics of membrane nanomechanics upon PTP-GNP treatment in pancreatic cancer cell lines. (A) Schematic of AFM experimental setup. (B) Pictorial representation of Panc1 cell morphology. (C) A representative F–S curve. (D) Schematic representing a receptor mediated interaction between PTP-GNP and surface plectin-1 receptors. Alteration in Panc1 cells’ nanomechanical properties upon PTP-GNP treatment: (E) membrane stiffness, (F) deformation, and (G) adhesion. Alteration in 4911 cells’ nanomechanical properties upon PTP-GNP treatment: (H) membrane stiffness, (I) deformation, and (J) adhesion.