Figure 5.

Effects of sucrose pellet devaluation on choice preference and other task variables. Only rats receiving intra-lOFC RS 102221 shifted their choice profile (A) and completed significantly fewer trials (B) in response to devaluation. Animals in all groups exhibited a significant reduction in premature responding (C) and increased choice latencies (D). No shift in latencies to collect reward were observed in any group (E). In panel A, data are expressed as the mean change in % choice from baseline ± SEM to illustrate effects independent of differences in preference for each option between cohorts. Data are expressed as mean ± SEM in all other panels; *p < 0.05, **p < 0.01, ****p < 0.0001, #p = 0.07 compared with each group’s own baseline.