Skip to main content
. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2021 Nov 9;54:128443. doi: 10.1016/j.bmcl.2021.128443

Scheme 3.

Scheme 3.

i, 1-(3-methylpyridin-2-yl)ethan-1-one, KOH, MeOH, 20 °C, 3 days, 63%; ii, malononitrile, NaOMe, MeOH, 20 °C, 16 h, 38%; iii, HCl, dioxane/CH2Cl2, MeOH, 20 °C, 16 h, 99%.