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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2021 Nov 9;54:128443. doi: 10.1016/j.bmcl.2021.128443

Table 2.

Calculated properties for the most potent SAR class A’ analogs

graphic file with name nihms-1758270-t0004.jpg
Compound A B C IC50 (nM) tPSA clogP
1 graphic file with name nihms-1758270-t0005.jpg graphic file with name nihms-1758270-t0006.jpg Me 25 45.38 5.17
14 graphic file with name nihms-1758270-t0007.jpg graphic file with name nihms-1758270-t0008.jpg Me 14 57.74 3.954
15 graphic file with name nihms-1758270-t0009.jpg graphic file with name nihms-1758270-t0010.jpg Me 8.7 57.74 4.153
16 graphic file with name nihms-1758270-t0011.jpg graphic file with name nihms-1758270-t0012.jpg graphic file with name nihms-1758270-t0013.jpg 5.5 57.74 4.728
18 graphic file with name nihms-1758270-t0014.jpg graphic file with name nihms-1758270-t0015.jpg graphic file with name nihms-1758270-t0016.jpg 36 70.1 4.024
19 graphic file with name nihms-1758270-t0017.jpg graphic file with name nihms-1758270-t0018.jpg Me 29 83.76 2.966