Table 2. Interactive effects of 2-way ANOVA for PPO expression and phenoloxidase activity (qPCR Type III Fixed effects).

Arrows indicate up or down-regulation of gene expression during fungal or Wolbachia infection.

	Target	Effect	Ae. albopictus			Cx. pipiens
			Num/Den DF	F Value	Pr>F	Num/Den DF	F Value	Pr>F
Pro-phenoloxidase	PPO1	F	2/53	↑58.07	<0.0001	2/59	↑3.86	0.0265
		W	1/53	0.21	0.6523	1/59	0.07	0.7967
		F*W	2/53	0.17	0.8444	2/59	0.61	0.5482
	PPO2	F				2/54	↑33.28	<0.0001
		W		-		1/54	0.74	0.3949
		F*W				2/54	8.7	0.0005
	PPO3	F	2/53	↑5.14	0.0091	2/56	↑13.85	<0.0001
		W	1/53	0.11	0.7381	1/56	7.28	0.0092
		F*W	2/53	0.17	0.8455	2/56	1.07	0.3484
	PPO4	F	2/54	1.25	0.2949	2/59	↑10.22	0.0002
		W	1/54	2.32	0.1335	1/59	0.97	0.3276
		F*W	2/54	0.92	0.4033	2/59	0.96	0.3887
	PPO05	F	2/52	0.63	0.538	2/58	2.44	0.0961
		W	1/52	↑4.27	0.0437	1/58	↓4.23	0.0442
		F*W	2/52	1.60	0.2118	2/58	0.66	0.5186
	PPO6	F	2/55	↑4.98	0.0103	2/59	1.08	0.3475
		W	1/55	2.75	0.1029	1/59	↓4.61	0.0359
		F*W	2/55	1.26	0.2923	2/59	2.24	0.1155
	PPO7	F	2/53	1.39	0.2589	2/54	↑15.25	<0.0001
		W	1/53	2.99	0.0898	1/54	1.32	0.2563
		F*W	2/53	0.54	0.5845	2/54	0.41	0.6638
	PPO8	F	2/52	↑60.97	<0.0001
		W	1/52	0.82	0.3693
		F*W	2/52	0.55	0.5815
	PPO9	F				2/56	↑6.32	0.0034
		W				1/56	1.92	0.1712
		F*W				2/56	1	0.3726
Phenoloxidase	Phenoloxidase Activity	F	2/18	1.62	0.2254	2/18	↑4.37	0.0284
		W	1/18	0.25	0.6251	1/18	0.93	0.3475
		F*W	2/18	1.94	0.1719	2/18	0.12	0.8843