Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 11;20:139–147. doi: 10.1016/j.csbj.2021.12.011

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 5 — The FA site allosterically affects the furin cleavage/recognition site, the fusion peptide proximal region (FPPR), and the residues immediately preceding the S2′ cleavage site in the SARS-CoV-2 spike. Average Cα-positional deviations around the first FA site at times 0, 0.1, 1, 3 and 5 ns following LA removal from the FA binding pockets. This figure shows the response around the first FA binding site, which is formed by monomers A and C. A similar response is observed for all three monomers (see Figs. S18-S19 for the responses observed for the other two FA sites). Analogous connections between the other two FA sites and the furin cleavage/recognition sites, FPPR and S2′ cleavage sites are also observed (Figs. S17-S18). For more details, see the legend of Fig. 3.