FIG. 7.

(A) Structure of the analyzed AP promoters from the corresponding mouse (m), rat (r), or human (h) genes. Open ovals, C/EBP–type I IL-6RE sites; solid rectangles, STAT–type II IL-6RE sites; shaded rectangles, proposed STAT sites which have not been functionally characterized; dotted oval on the rat FBα promoter, potential C/EBP site that was found not to be functional. The position and sequence of each STAT element is shown, and previous nomenclature is also given when appropriate. The coordinates of each promoter are indicated, and elements identified on the promoters but not involved in cytokine responsiveness are named and indicated by arrows. Both the distal (DRE) and the Proximal (PRE) regulatory regions of the rat AGP gene are shown. The glucocorticoid responsive element (GRE) contained within the PRE is required for optimal induction. References are given in the text. (B) Sequence comparison of the C/EBP sites on the human, mouse, and rat Hpx promoters. Bases mutated in the mouse and rat promoters compared to the human sequence are in boldface and underlined.