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. 2021 Dec 15;131(24):e140436. doi: 10.1172/JCI140436

Figure 5. Hyperglycemia induced by PI3K inhibitor treatment is attenuated by the inhibition of WWP1.

Figure 5

(A) Mean ± SD of blood glucose levels in mice treated with vehicle or BKM120 (50 mg/kg, n = 9 per group). (B) Mean ± SD of blood insulin levels assessed 3 hours after BKM120 administration (n = 7 per group). (C) Mean ± SD of blood glucose levels in mice after treatment with vehicle or BKM120 (50 mg/kg). Mice (n = 6 per group) were pretreated with vehicle, I3C (50 mg/kg), or metformin (MET, 200 mg/kg) for 7 days. (D) Mean ± SD of blood insulin levels assessed 3 hours after BKM120 treatment (n = 6 per group). *P < 0.05, **P < 0.01, and ***P < 0.005, by repeated-measures 2-way ANOVA followed by Tukey-Kramer multiple-comparison test (A and C) and 1-way ANOVA followed by Tukey-Kramer multiple-comparison test (B and D).