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In general, circEsyt2 binds to PCBP1 in the cytoplasm and sequesters it from nuclear translocation. Reduction of nuclear PCBP1 suppresses U2AF65-dependent p53β splicing, which may alter the expression of p53-regulated proliferation and apoptosis genes. Consequently, VSMCs excessively proliferate, contributing to the development and progression of vascular remodeling.
