Table 2.
Overall Comparison and Pairwise Comparison of Each Group in Kaplan–Meier Survival Analysis
| Comparison Type | Comparative Factor | Log Rank (Mantel-Cox) | Breslow (Generalized Wilcoxon) | Tarone-Ware | |||
|---|---|---|---|---|---|---|---|
| Chi Square | Sig. | Chi Square | Sig. | Chi Square | Sig. | ||
| Overall comparison | Sex | 3,119.588 | 0.000 | 2,577.577 | 0.000 | 2,934.977 | 0.000 |
| Age | 36,486.760 | 0.000 | 33,627.846 | 0.000 | 34,681.780 | 0.000 | |
| Race | 1,300.355 | 0.000 | 1,210.942 | 0.000 | 1,311.907 | 0.000 | |
| Origin recode NHIA | 10.506 | 0.001 | 0.624 | 0.429 | 0.323 | 0.570 | |
| Median household income inflation adj to 2019 | 3,119.588 | 0.000 | 2,577.577 | 0.000 | 2,934.977 | 0.000 | |
| Rural-Urban Continuum Code | 1,952.945 | 0.000 | 1,397.391 | 0.000 | 1,696.331 | 0.000 | |
| Primary site | 56,749.667 | 0.000 | 57,432.600 | 0.000 | 59,443.510 | 0.000 | |
| Histologic type (ICD-O-3) | 82,913.123 | 0.000 | 79,928.300 | 0.000 | 84,548.100 | 0.000 | |
| Year of diagnosis | 7,532.042 | 0.000 | 5,692.115 | 0.000 | 6,834.910 | 0.000 | |
| Summary stage | 240,670.146 | 0.000 | 219,186.158 | 0.000 | 239,656.003 | 0.000 | |
| Pairwise comparison | Sex | ||||||
| Female vs Male | 9,473.321 | 0.000 | 7,344.132 | 0.000 | 8,697.481 | 0.000 | |
| Age | |||||||
| < 45 years vs 45–54 years | 658.146 | 0.000 | 451.420 | 0.000 | 535.237 | 0.000 | |
| < 45 years vs 55–64 years | 1,186.997 | 0.000 | 755.752 | 0.000 | 891.847 | 0.000 | |
| < 45 years vs 65–74 years | 2,134.621 | 0.000 | 1,209.475 | 0.000 | 1,450.388 | 0.000 | |
| < 45 years vs 75–84 years | 5,280.355 | 0.000 | 3,281.758 | 0.000 | 3,847.412 | 0.000 | |
| < 45 years vs ≥ 85 years | 9,405.387 | 0.000 | 7,374.587 | 0.000 | 8,275.701 | 0.000 | |
| 45–54 years vs 55–64 years | 168.537 | 0.000 | 131.890 | 0.000 | 125.492 | 0.000 | |
| 45–54 years vs 65–74 years | 1,135.723 | 0.000 | 766.972 | 0.000 | 783.114 | 0.000 | |
| 45–54 years vs 75–84 years | 7,332.664 | 0.000 | 5,949.599 | 0.000 | 6,199.769 | 0.000 | |
| 45–54 years vs≥ 85 years | 16,522.957 | 0.000 | 16,185.395 | 0.000 | 16,484.200 | 0.000 | |
| 55–64 years vs 65–74 years | 734.202 | 0.000 | 495.365 | 0.000 | 520.272 | 0.000 | |
| 55–64 years vs 75–84 years | 9,978.407 | 0.000 | 8,503.476 | 0.000 | 8,906.353 | 0.000 | |
| 55–64 years vs≥ 85 years | 21,880.320 | 0.000 | 21,656.557 | 0.000 | 22,006.761 | 0.000 | |
| 65–74 years vs 75–84 years | 7,052.078 | 0.000 | 6,213.807 | 0.000 | 6,581.952 | 0.000 | |
| 65–74 years vs≥ 85 years | 19,673.925 | 0.000 | 19,042.105 | 0.000 | 19,640.948 | 0.000 | |
| 75–84 years vs ≥ 85 years | 6,915.700 | 0.000 | 6,358.064 | 0.000 | 6,757.770 | 0.000 | |
| Race | |||||||
| White vs Black | 278.487 | 0.000 | 106.505 | 0.000 | 189.853 | 0.000 | |
| White vs Asian and other races | 918.554 | 0.000 | 1,032.227 | 0.000 | 1,028.928 | 0.000 | |
| Black vs Asian and other races | 1,325.507 | 0.000 | 1,162.642 | 0.000 | 1,310.095 | 0.000 | |
| Origin recode NHIA | |||||||
| Non-Spanish-Hispanic-Latino vs Spanish-Hispanic-Latino | 10.506 | 0.001 | 0.624 | 0.429 | 0.323 | 0.570 | |
| Median household income inflation adj to 2019 | |||||||
| < $35,000 vs $35,000-$44,999 | 42.062 | 0.000 | 33.672 | 0.000 | 40.737 | 0.000 | |
| < $35,000 vs $45,000-$54,999 | 85.564 | 0.000 | 68.062 | 0.000 | 81.767 | 0.000 | |
| < $35,000 vs $55,000-$64,999 | 230.631 | 0.000 | 172.090 | 0.000 | 206.247 | 0.000 | |
| < $35,000 vs $65,000-$74,999 | 431.627 | 0.000 | 337.420 | 0.000 | 396.074 | 0.000 | |
| < $35,000 vs $75,000+ | 811.362 | 0.000 | 684.642 | 0.000 | 774.900 | 0.000 | |
| < $35,000 vs Others | 2.197 | 0.138 | 4.895 | 0.027 | 4.144 | 0.042 | |
| $35,000-$44,999 vs $45,000-$54,999 | 16.965 | 0.000 | 12.927 | 0.000 | 15.542 | 0.000 | |
| $35,000-$44,999 vs $55,000-$64,999 | 214.341 | 0.000 | 144.686 | 0.000 | 176.486 | 0.000 | |
| $35,000-$44,999 vs $65,000-$74,999 | 588.760 | 0.000 | 440.256 | 0.000 | 520.033 | 0.000 | |
| $35,000-$44,999 vs $75,000+ | 1,464.530 | 0.000 | 1,219.404 | 0.000 | 1,378.889 | 0.000 | |
| $35,000-$44,999 vs Others | 1.005 | 0.316 | 3.174 | 0.075 | 2.395 | 0.122 | |
| $45,000-$54,999 vs $55,000-$64,999 | 176.365 | 0.000 | 107.494 | 0.000 | 134.260 | 0.000 | |
| $45,000-$54,999 vs $65,000-$74,999 | 636.716 | 0.000 | 461.262 | 0.000 | 549.033 | 0.000 | |
| $45,000-$54,999 vs $75,000+ | 1,882.057 | 0.000 | 1,547.162 | 0.000 | 1,755.248 | 0.000 | |
| $45,000-$54,999 vs Others | 0.699 | 0.403 | 2.703 | 0.100 | 1.938 | 0.164 | |
| $55,000-$64,999 vs $65,000-$74,999 | 177.901 | 0.000 | 155.032 | 0.000 | 175.937 | 0.000 | |
| $55,000-$64,999 vs $75,000+ | 1,064.955 | 0.000 | 995.599 | 0.000 | 1,088.148 | 0.000 | |
| $55,000-$64,999 vs Others | 0.219 | 0.640 | 1.752 | 0.186 | 1.068 | 0.301 | |
| $65,000-$74,999 vs $75,000+ | 314.574 | 0.000 | 308.995 | 0.000 | 328.720 | 0.000 | |
| $65,000-$74,999 vs Others | 0.007 | 0.933 | 0.987 | 0.321 | 0.450 | 0.502 | |
| $75,000+ vs Others | 0.160 | 0.690 | 0.267 | 0.605 | 0.029 | 0.864 | |
| Rural-Urban Continuum Code | |||||||
| Counties in metropolitan areas greater than 1 million population vs Counties in metropolitan areas of 250,000 to 1 million population | 154.789 | 0.000 | 89.246 | 0.000 | 118.829 | 0.000 | |
| Counties in metropolitan areas greater than 1 million population vs Counties in metropolitan areas of less than 250 thousand population | 489.541 | 0.000 | 339.405 | 0.000 | 414.594 | 0.000 | |
| Counties in metropolitan areas greater than 1 million population vs Nonmetropolitan counties adjacent to a metropolitan area | 898.955 | 0.000 | 628.695 | 0.000 | 771.331 | 0.000 | |
| Counties in metropolitan areas greater than 1 million population vs Nonmetropolitan counties not adjacent to a metropolitan area | 1,002.371 | 0.000 | 758.392 | 0.000 | 899.192 | 0.000 | |
| Counties in metropolitan areas greater than 1 million population vs Others | 22.407 | 0.000 | 9.820 | 0.002 | 15.310 | 0.000 | |
| Counties in metropolitan areas of 250,000 to 1 million population vs Counties in metropolitan areas of less than 250 thousand population | 132.516 | 0.000 | 103.077 | 0.000 | 119.878 | 0.000 | |
| Counties in metropolitan areas of 250,000 to 1 million population vs Nonmetropolitan counties adjacent to a metropolitan area | 343.469 | 0.000 | 256.190 | 0.000 | 307.174 | 0.000 | |
| Counties in metropolitan areas of 250,000 to 1 million population vs Nonmetropolitan counties not adjacent to a metropolitan area | 471.405 | 0.000 | 381.350 | 0.000 | 441.650 | 0.000 | |
| Counties in metropolitan areas of 250,000 to 1 million population vs Others | 12.395 | 0.000 | 4.685 | 0.030 | 7.959 | 0.005 | |
| Counties in metropolitan areas of less than 250 thousand population vs Nonmetropolitan counties adjacent to a metropolitan area | 36.154 | 0.000 | 24.804 | 0.000 | 31.550 | 0.000 | |
| Counties in metropolitan areas of less than 250 thousand population vs Nonmetropolitan counties not adjacent to a metropolitan area | 102.205 | 0.000 | 84.179 | 0.000 | 98.169 | 0.000 | |
| Counties in metropolitan areas of less than 250 thousand population vs Others | 3.187 | 0.074 | 0.355 | 0.551 | 1.314 | 0.252 | |
| Nonmetropolitan counties adjacent to a metropolitan area vs Nonmetropolitan County not adjacent to a metropolitan area | 21.335 | 0.000 | 21.435 | 0.000 | 22.933 | 0.000 | |
| Nonmetropolitan counties adjacent to a metropolitan area vs Others | 0.529 | 0.467 | 0.090 | 0.764 | 0.022 | 0.882 | |
| Nonmetropolitan counties not adjacent to a metropolitan area vs Others | 0.031 | 0.860 | 1.436 | 0.231 | 0.617 | 0.432 | |
| Primary site | |||||||
| Right upper lobe vs Right middle lobe | 162.922 | 0.000 | 80.685 | 0.000 | 116.572 | 0.000 | |
| Right upper lobe vs Right lower lobe | 54.723 | 0.000 | 68.757 | 0.000 | 64.783 | 0.000 | |
| Right upper lobe vs Left upper lobe | 168.685 | 0.000 | 76.857 | 0.000 | 122.258 | 0.000 | |
| Right upper lobe vs Left lower lobe | 19.496 | 0.000 | 15.767 | 0.000 | 19.963 | 0.000 | |
| Right upper lobe vs Main bronchus | 10,216.526 | 0.000 | 10,257.262 | 0.000 | 10,769.433 | 0.000 | |
| Right upper lobe vs Over lapping lesion of lung | 595.338 | 0.000 | 829.226 | 0.000 | 770.682 | 0.000 | |
| Right upper lobe vs Lung, NOS | 37,093.583 | 0.000 | 36,323.045 | 0.000 | 38,235.231 | 0.000 | |
| Right upper lobe vs Others | 699.934 | 0.000 | 612.111 | 0.000 | 668.653 | 0.000 | |
| Right middle lobe vs Right lower lobe | 263.986 | 0.000 | 173.472 | 0.000 | 217.803 | 0.000 | |
| Right middle lobe vs Left upper lobe | 383.715 | 0.000 | 183.845 | 0.000 | 276.207 | 0.000 | |
| Right middle lobe vs Left lower lobe | 203.992 | 0.000 | 112.926 | 0.000 | 158.356 | 0.000 | |
| Right middle lobe vs Main bronchus | 6,517.198 | 0.000 | 5,704.728 | 0.000 | 6,423.992 | 0.000 | |
| Right middle lobe vs Over lapping lesion of lung | 779.740 | 0.000 | 877.108 | 0.000 | 882.311 | 0.000 | |
| Right middle lobe vs Lung, NOS | 13,575.417 | 0.000 | 11,318.686 | 0.000 | 13,058.521 | 0.000 | |
| Right middle lobe vs Others | 827.004 | 0.000 | 682.774 | 0.000 | 765.542 | 0.000 | |
| Right lower lobe vs Left upper lobe | 13.780 | 0.000 | 0.580 | 0.446 | 2.000 | 0.157 | |
| Right lower lobe vs Left lower lobe | 4.529 | 0.033 | 10.831 | 0.001 | 6.940 | 0.008 | |
| Right lower lobe vs Main bronchus | 7,741.953 | 0.000 | 7,473.661 | 0.000 | 8,027.688 | 0.000 | |
| Right lower lobe vs Over lapping lesion of lung | 446.655 | 0.000 | 621.232 | 0.000 | 581.078 | 0.000 | |
| Right lower lobe vs Lung, NOS | 23,928.595 | 0.000 | 22,385.509 | 0.000 | 24,235.716 | 0.000 | |
| Right lower lobe vs Others | 609.686 | 0.000 | 513.797 | 0.000 | 571.712 | 0.000 | |
| Left upper lobe vs Left lower lobe | 33.598 | 0.000 | 8.632 | 0.003 | 17.905 | 0.000 | |
| Left upper lobe vs Main bronchus | 8,554.529 | 0.000 | 8,966.598 | 0.000 | 9,271.170 | 0.000 | |
| Left upper lobe vs Over lapping lesion of lung | 419.865 | 0.000 | 684.012 | 0.000 | 599.494 | 0.000 | |
| Left upper lobe vs Lung, NOS | 30,093.214 | 0.000 | 30,515.243 | 0.000 | 31,760.602 | 0.000 | |
| Left upper lobe vs Others | 604.525 | 0.000 | 551.023 | 0.000 | 591.460 | 0.000 | |
| Left lower lobe vs Main bronchus | 7,605.617 | 0.000 | 7,473.549 | 0.000 | 7,956.885 | 0.000 | |
| Left lower lobe vs Over lapping lesion of lung | 487.337 | 0.000 | 692.059 | 0.000 | 636.294 | 0.000 | |
| Left lower lobe vs Lung, NOS | 21,655.850 | 0.000 | 20,479.488 | 0.000 | 22,098.264 | 0.000 | |
| Left lower lobe vs Others | 639.715 | 0.000 | 558.856 | 0.000 | 611.053 | 0.000 | |
| Main bronchus vs Over lapping lesion of lung | 574.941 | 0.000 | 374.213 | 0.000 | 491.592 | 0.000 | |
| Main bronchus vs Lung, NOS | 482.626 | 0.000 | 590.283 | 0.000 | 555.427 | 0.000 | |
| Main bronchus vs Others | 1.595 | 0.207 | 8.097 | 0.004 | 5.825 | 0.016 | |
| Over lapping lesion of lung vs Lung, NOS | 1,416.129 | 0.000 | 1,047.110 | 0.000 | 1,270.005 | 0.000 | |
| Over lapping lesion of lung vs Others | 122.072 | 0.000 | 55.546 | 0.000 | 83.040 | 0.000 | |
| Lung, NOS vs Others | 52.256 | 0.000 | 91.285 | 0.000 | 79.609 | 0.000 | |
| Right upper lobe vs Other single lobes | 71.499 | 0.000 | 53.158 | 0.000 | 66.958 | 0.000 | |
| Right middle lobe vs Other single lobes | 284.671 | 0.000 | 149.788 | 0.000 | 212.357 | 0.000 | |
| Right lower lobe vs Other single lobes | 21.601 | 0.000 | 43.991 | 0.000 | 32.919 | 0.000 | |
| Left upper lobe vs Other single lobes | 174.418 | 0.000 | 57.640 | 0.000 | 108.889 | 0.000 | |
| Left lower lobe vs Other single lobes | 0.963 | 0.326 | 1.070 | 0.301 | 1.432 | 0.231 | |
| Main bronchus vs Single lobes | 11,026.346 | 0.000 | 11,283.718 | 0.000 | 11,727.875 | 0.000 | |
| Over lapping lesion of lung vs Single lobes | 547.887 | 0.000 | 786.542 | 0.000 | 722.280 | 0.000 | |
| Lung, NOS vs Single lobes | 50,039.338 | 0.000 | 51,295.080 | 0.000 | 52,602.027 | 0.000 | |
| Histologic type (ICD-O-3) | |||||||
| Neoplasia, NAS vs Epithelial neoplasms, NAS | 3,757.214 | 0.000 | 7,408.176 | 0.000 | 5,986.605 | 0.000 | |
| Neoplasia, NAS vs Squamous cell neoplasms | 20,217.196 | 0.000 | 27,516.738 | 0.000 | 25,146.774 | 0.000 | |
| Neoplasia, NAS vs Adenoma and adenocarcinomas | 35,445.959 | 0.000 | 40,577.637 | 0.000 | 39,259.802 | 0.000 | |
| Neoplasia, NAS vs Cystic, mucinous and serous neoplasms | 6,149.905 | 0.000 | 6,029.979 | 0.000 | 6,450.057 | 0.000 | |
| Neoplasia, NAS vs Acinous cell neoplasm | 11,950.640 | 0.000 | 10,107.204 | 0.000 | 11,760.036 | 0.000 | |
| Neoplasia, NAS vs Complex epithelial neoplasms | 4,939.508 | 0.000 | 5,491.534 | 0.000 | 5,632.441 | 0.000 | |
| Neoplasia, NAS vs Others | 1,961.725 | 0.000 | 1,547.515 | 0.000 | 1,799.985 | 0.000 | |
| Epithelial neoplasms, NAS vs Squamous cell neoplasms | 18,051.629 | 0.000 | 18,642.122 | 0.000 | 19,723.395 | 0.000 | |
| Epithelial neoplasms, NAS vs Adenoma and adenocarcinomas | 52,956.139 | 0.000 | 43,604.909 | 0.000 | 49,887.906 | 0.000 | |
| Epithelial neoplasms, NAS vs Cystic, mucinous and serous neoplasms | 3,920.902 | 0.000 | 2,832.710 | 0.000 | 3,530.938 | 0.000 | |
| Epithelial neoplasms, NAS vs Acinous cell neoplasm | 9,902.939 | 0.000 | 8,306.628 | 0.000 | 9,832.557 | 0.000 | |
| Epithelial neoplasms, NAS vs Complex epithelial neoplasms | 2,880.374 | 0.000 | 2,512.595 | 0.000 | 2,904.016 | 0.000 | |
| Neoplasia, NAS vs Complex epithelial neoplasms | 4,939.508 | 0.000 | 5,491.534 | 0.000 | 5,632.441 | 0.000 | |
| Epithelial neoplasms, NAS vs Others | 1,183.182 | 0.000 | 575.683 | 0.000 | 841.398 | 0.000 | |
| Squamous cell neoplasms vs Adenoma and adenocarcinomas | 4,324.050 | 0.000 | 2,002.280 | 0.000 | 2,974.305 | 0.000 | |
| Squamous cell neoplasms vs Cystic, mucinous and serous neoplasms | 526.311 | 0.000 | 232.401 | 0.000 | 355.225 | 0.000 | |
| Squamous cell neoplasms vs Acinous cell neoplasm | 5,171.203 | 0.000 | 4,982.770 | 0.000 | 5,383.737 | 0.000 | |
| Squamous cell neoplasms vs Complex epithelial neoplasms | 246.850 | 0.000 | 171.523 | 0.000 | 210.048 | 0.000 | |
| Squamous cell neoplasms vs Others | 211.562 | 0.000 | 15.811 | 0.000 | 64.762 | 0.000 | |
| Adenoma and adenocarcinomas vs Cystic, mucinous and serous neoplasms | 9.479 | 0.002 | 4.511 | 0.034 | 6.611 | 0.010 | |
| Adenoma and adenocarcinomas vs Acinous cell neoplasm | 3,429.157 | 0.000 | 3,748.082 | 0.000 | 3,805.019 | 0.000 | |
| Adenoma and adenocarcinomas vs Complex epithelial neoplasms | 14.960 | 0.000 | 0.000 | 0.991 | 2.697 | 0.101 | |
| Adenoma and adenocarcinomas vs Others | 10.571 | 0.001 | 7.914 | 0.005 | 0.424 | 0.515 | |
| Cystic, mucinous and serous neoplasms vs Acinous cell neoplasm | 2,508.321 | 0.000 | 3,023.062 | 0.000 | 2,957.332 | 0.000 | |
| Cystic, mucinous and serous neoplasms vs Complex epithelial neoplasms | 24.420 | 0.000 | 2.074 | 0.150 | 8.732 | 0.003 | |
| Cystic, mucinous and serous neoplasms vs Others | 0.961 | 0.327 | 12.862 | 0.000 | 3.988 | 0.046 | |
| Acinous cell neoplasm vs Complex epithelial neoplasms | 2,915.827 | 0.000 | 3,292.872 | 0.000 | 3,306.154 | 0.000 | |
| Acinous cell neoplasm vs Others | 1,432.131 | 0.000 | 2,382.199 | 0.000 | 2,110.827 | 0.000 | |
| Complex epithelial neoplasms vs Others | 20.792 | 0.000 | 6.543 | 0.011 | 0.027 | 0.871 | |
| Summary stage | |||||||
| Distant vs Localized | 189,234.197 | 0.000 | 157,689.763 | 0.000 | 180,494.909 | 0.000 | |
| Distant vs Regional | 95,182.979 | 0.000 | 89,552.783 | 0.000 | 97,474.996 | 0.000 | |
| Distant vs Unknown/unstaged | 2,281.394 | 0.000 | 1,319.592 | 0.000 | 1,873.692 | 0.000 | |
| Localized vs Regional | 22,646.800 | 0.000 | 24,779.500 | 0.000 | 25,260.467 | 0.000 | |
| Localized vs Unknown/unstaged | 54,328.909 | 0.000 | 60,221.013 | 0.000 | 59,752.077 | 0.000 | |
| Regional vs Unknown/unstaged | 15,840.215 | 0.000 | 19,402.780 | 0.000 | 18,494.477 | 0.000 | |