Table 4.

Skin histopathological changes at the end of Day 14 in different rat groups following 14-day administration of various formulations on wound tissues.

	No treatment (control)	Cold cream	L. fermentum cold cream	L. reuteri cold cream	B.S. natto cold cream
Epithelization	Incomplete	Incomplete (deep)	Incomplete (super)	Complete	Complete
Inflammation	++	++	++	−∗	+∗
Granulation	++	++	+∗	−∗	−∗
Fibrosis	++	+∗	+∗	+∗	+∗

− means no significant change (P > 0.05); + and ++ mean mild (P < 0.05) and moderate (P < 0.001) histopathological significant changes, respectively. ^∗Significant histopathological changes in comparison to the no-treatment group (control) (P < 0.05).