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. 2021 Dec 7;2021:7674565. doi: 10.1155/2021/7674565

Figure 3.

Figure 3

Cysteine depletion blocks the GSH/GPX4 pathway in both K562/G01 and K562 cells. (a) The levels of GSH were tested in K562/G01 and K562 cells cultured in normal or cysteine depletion condition for 24 h. (b) The activity of GPX4 was tested in K562/G01 and K562 cells cultured in normal or cysteine depletion condition for 24 h. GSH represents for reduced glutathione; GPX4 represents for glutathione peroxidase 4; control represents for normal condition (0.0652 g/L cysteine). Treat represents for cysteine depletion condition (0 g/L cysteine). Experiments were repeated three times, and the data are expressed as the mean ± SEM. ∗∗∗P < 0.001 vs. control group.