Figure 7.

Schematic representation of the mechanisms of TXNRD1 regulates ferroptosis induced by cysteine depletion in CML cells. When the intracellular cysteine is sufficient, TXNRD1 and GSH/GPX4 work together to maintain the intracellular redox balance, avoiding cell oxidative damage and even ferroptosis. When intracellular cysteine is deficient, cysteine depletion will cause a certain degree of TXNRD1 enzyme activity and GSH/GPX4 levels decrease, leading to a sharp increase of ROS levels and the occurrence of ferroptosis, which negatively feedback upregulates the expression of TXNRD1 gene.