Table 3.
Summary of mRNA fold changes in mutant Tau-HT22 cells relative control HT22 cells and mitophagy enhancers treated in mutant Tau-HT22 treated cells relative to mutant Tau-HT22 untreated cells
|
Genes |
mRNA fold change in mTau HT22 cells | mRNA fold change in nicotinamide riboside treated mTau | mRNA fold change in tomatidine treated mTau | mRNA fold change in urolithin A treated mTau | mRNA fold change in actinonin treated mTau | |
|---|---|---|---|---|---|---|
| Mitochondrial structural genes | Drp1 | 2.44*** | −1.38 | −1.61* | −2.22** | −2.04* |
| Fis1 | 1.57** | −1.33 | −1.31* | −1.78** | −1.19 | |
| Mfn1 | −1.81* | 1.36 | 1.96** | 2.75*** | 1.18 | |
| Mfn2 | −1.53 | 2.32*** | 2.44*** | 5.32**** | 1.52** | |
| OPA1 | −2.77* | 1.97* | 1.63 | 2.89** | 1.66* | |
| Biogenesis genes | PGC1α | −1.44 | 1.65 | 1.74 | 2.2* | 1.35 |
| Nrf1 | −2.43* | 1.75* | 1.57* | 2.51*** | 1.43* | |
| Nrf2 | −1.33 | 1.17 | 1.36* | 1.7* | 1.1 | |
| TFAM | −3.03 | 7.09**** | 8.15**** | 9.58**** | 1.35 | |
| Synaptic genes Mitophagy genes | Synaptophysin | −1.47 | 3.81 | 8.44**** | 9.54**** | 4.05 |
| PINK1 | −2.38 | 6.69**** | 3.77*** | 7.53**** | 3.05 | |
| Parkin | −1.45 | 3.4 | 2.9* | 3.89** | 2.64* |