TABLE 1.
The modification results of m6A, m5C, and m1A methylation in various RNA.
| RNA type | Regulators | Modification type | Functional consequences | PMID |
|---|---|---|---|---|
| mRNA | YTHDF2 | m6A | Enhance stability | 29,476,152 |
| mRNA | YTHDC1 | m6A | Promote export | 30,218,090 |
| mRNA | ALKBH5 | m6A | Promote export | 23,177,736 |
| mRNA | METTL3 | m6A | Elevate translational efficiency | 27,117,702 |
| mRNA | METTL14 | m6A | Elevate translational efficiency | 24,284,625 |
| mRNA | ALYREF | m5C | Promote export | 28,418,038 |
| mRNA | NSUN2 | m5C | Promote transport and affect protein synthesis (promote, and inhibit) | 25,063,673 |
| tRNA | NSUN2 | m5C | Enhance stability and promote survival proteins synthesis to repose stress | 28,062,751 |
| rRNA | NSUN5 | m5C | Enhance stability | 27,167,997 |
| mRNA | — | m1A | Enhance stability and affect translation efficiency (promote, and inhibit) | 28,230,814 |
| tRNA | — | m1A | Promote HIV replication | 29,908,293 |
| tRNA | ALKBH1 | m1A | Enhance stability | 27,984,735 |