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. 2021 Dec 15;44(11):903–986. doi: 10.1007/s12272-021-01354-2

Table 11.

Alkaloids isolated from Sophora species

No. Name Plant species Structure References
232 Sophovicine A S. davidii graphic file with name 12272_2021_1354_Figdj_HTML.gif Zhang et al. (2021c)
233 Sophovicine B S. davidii graphic file with name 12272_2021_1354_Figdk_HTML.gif Zhang et al. (2021c)
234 Sophovicine C S. davidii graphic file with name 12272_2021_1354_Figdl_HTML.gif Zhang et al. (2021c)
235 Sophocarpine

S. alopecuroides

S. flavescens

S. japonica

S. moorcroftiana

S. tonkinensis

S. viciifolia

graphic file with name 12272_2021_1354_Figdm_HTML.gif Ao et al. (2019), He et al. (2019), Cao and He (2020), Li et al. (2020d)
236 Oxysophocarpine S. flavescens graphic file with name 12272_2021_1354_Figdn_HTML.gif Wang et al. (2019a)
237 9 α-Hydroxysophocarpine S. flavescens graphic file with name 12272_2021_1354_Figdo_HTML.gif Wang et al. (2019a)
238 12α-Hydroxysophocarpine

S. flavescens

S. viciifolia

graphic file with name 12272_2021_1354_Figdp_HTML.gif Ao et al. (2019), Wang et al. (2019a)
239 12 β -Hydroxy-sophocarpine S. alopecuroides graphic file with name 12272_2021_1354_Figdq_HTML.gif Li et al. (2020d)
240 Sophoridine

S. alopecuroides

S. flavescens

S. japonica

graphic file with name 12272_2021_1354_Figdr_HTML.gif Zhang et al. (2018b), Wang et al. (2019a), Li et al. (2019c), Cao and He (2020), Li et al. (2020d)
241 Isosophoridine

S. flavescens

S. japonica

graphic file with name 12272_2021_1354_Figds_HTML.gif Zhang et al. (2018b)
242 10-Oxysophoridine

S. flavescens

S. japonica

graphic file with name 12272_2021_1354_Figdt_HTML.gif Zhang et al. (2018b)
243 Sophoramine

S. alopecuroides

S. flavescens

S. japonica

S. viciifolia

graphic file with name 12272_2021_1354_Figdu_HTML.gif Zhang et al. (2018b,c), Ao et al. (2019), Cao and He (2020), Elberry et al. (2020), Guo et al. (2020), Li et al. (2020d), Wang et al. (2020b)
244

7 α –Hydroxysophora-

mine

S. alopecuroides

S. japonica

graphic file with name 12272_2021_1354_Figdv_HTML.gif Li et al. (2020d)
245 9 α-Hydroxysophoramine S. flavescens graphic file with name 12272_2021_1354_Figdw_HTML.gif Wang et al. (2019a)
246 Matrine

S. alopecuroides

S. chrysophylla

S. flavescens

S. japonica

S. moorcroftiana

S. subprostrata

S. tomentosa

S. tonkinensis

S. viciifolia

graphic file with name 12272_2021_1354_Figdx_HTML.gif Ao et al. (2019), Fan et al. (2019), Li et al. (2019c), Wang et al. (2019a), Aly et al. (2020b), Cao and He (2020), Elberry et al. (2020), Guo et al. (2020), Li et al. (2020d), Zhang et al. (2020a, b, c)
247 Isomatrine S. flavescens graphic file with name 12272_2021_1354_Figdy_HTML.gif Wang et al. (2019a)
248 Allomatrine

S. flavescens

S. japonica

graphic file with name 12272_2021_1354_Figdz_HTML.gif Zhang et al. (2018b), Wang et al. (2019a)
249 Matrine N-oxide (Oxymatrine)

S. alopecuroides

S. chrysophylla

S. flavescens

S. japonica

S. macrocarpa

S. moorcroftiana

S. subprostrata

S. tomentosa

S. viciifolia

graphic file with name 12272_2021_1354_Figea_HTML.gif Zhang et al. (2018b, 2020a, b, c), Ao et al. (2019), Wang et al. (2019a), Cao and He (2020), Elberry et al. (2020), Gao et al. (2020), Guo et al. (2020), Li et al. (2020d), Liu et al. (2020a,b)
250 9α-Hydroxymatrine

S. alopecuroides

S. flavescens

S. macrocarpa

S. viciifolia

graphic file with name 12272_2021_1354_Figeb_HTML.gif Ao et al. (2019), Cao and He (2020), Gao et al. (2020), Li et al. (2020d)
251

5α-Hydroxymatrine [(+)-

Sophoranol]

S. flavescens

S. tonkinensis

graphic file with name 12272_2021_1354_Figec_HTML.gif Zhang et al. (2018b), He et al. (2019)
252 14β-Hydroxymatrine S. flavescens graphic file with name 12272_2021_1354_Figed_HTML.gif Zhang et al. (2018b)
253 7,11-Dehydromatrine (Leontalbinine)

S. flavescens

S. japonica

graphic file with name 12272_2021_1354_Figee_HTML.gif Zhang et al. (2018b, 2020a, b, c), Wang et al. (2019a), Cao and He (2020), Elberry et al. (2020), Guo et al. (2020)
254 9 α-Hydroxy- 7,11-dehydromatrine S. flavescens graphic file with name 12272_2021_1354_Figef_HTML.gif Wang et al. (2019a)
255 7,11-Dehydro-oxymatrine S. flavescens graphic file with name 12272_2021_1354_Figeg_HTML.gif Zhang et al. (2018b)
256 10-Oxy-5,6 dehydromatrine S. flavescens graphic file with name 12272_2021_1354_Figeh_HTML.gif Zhang et al. (2018b)
257 Lehmanine S. flavescens graphic file with name 12272_2021_1354_Figei_HTML.gif Wang et al. (2019a)
258 Flavascensine S. flavescens graphic file with name 12272_2021_1354_Figej_HTML.gif Wang et al. 2019a
259 Kurarimine S. flavescens graphic file with name 12272_2021_1354_Figek_HTML.gif Wang et al. (2019a)
260 Isokurarimine S. flavescens graphic file with name 12272_2021_1354_Figel_HTML.gif Wang et al. (2019a)
261 Epilamprolobin-N-oxide S. tomentosa graphic file with name 12272_2021_1354_Figem_HTML.gif Chang et al. (2019a, b), Wang et al. (2019a), Aly et al. (2020b)
262 Sophorasine A S. griffithii

graphic file with name 12272_2021_1354_Figen_HTML.gif

262: R1 = OH; R2 = H

263: R1 = H; R2 = OH

Zhang et al. (2020a, b, c)
263 Sophorasine B
264 Tsukushinamine A S. franchetiana graphic file with name 12272_2021_1354_Figeo_HTML.gif Boozari et al. (2019b)
265 Tsukushinamine B S. franchetiana graphic file with name 12272_2021_1354_Figep_HTML.gif Wang et al. (2019a)
266 Tsukushinamine C S. franchetiana graphic file with name 12272_2021_1354_Figeq_HTML.gif Zhang et al. (2020a, b, c)
267 Cytisine

S. alopecuroides

S. chrysophylla

S. franchetiana

S. korensis

S. macrocarpa

S. secundiflora

S. tomentosa

graphic file with name 12272_2021_1354_Figer_HTML.gif

267: R = H

Wang et al. (2019a), Chen et al. (2020d), Gao et al. (2020), Huang and Xu (2020a), Li et al. (2020d), Wang et al. (2020b), Zhang et al. (2020a, b, c)
268 N-methyl cytosine

S. alopecuroides

S. chrysophylla

S. flavescens

S. korensis

S. macrocarpa

S. secundiflora

S. tomentosa

268: R = CH3 Ao et al. (2019), Aly et al. (2020b), Cao and He (2020), Chen et al. (2020a), Huang and Xu (2020a), Gao et al. (2020), Li et al. (2020d), Wang et al. (2019a, 2020b)
269 N-formyl cytosine

S. alopecuroides

S. chrysophylla

S. franchetiana

S. korensis

S. secundiflora

S. tomentosa

269: R = CHO Wang et al. (2019a, 2020b), Aly et al. (2020b), Chen et al. (2020a), Gao et al. (2020), Huang and Xu (2020a), Li et al. (2020d)
270 Rhombifolin

S. chrysophylla

S. flavescens

S. franchetiana

S. korensis

S. secundiflora

270: R = CH2-CH2 = CH2

Wang et al. 2019a; Aly et al. 2020b; Cao and He 2020; Gao et al. 2020;

Zhang et al. 2020a, b, c

271 11-Oxocytisine S. secundiflora graphic file with name 12272_2021_1354_Figes_HTML.gif Wang et al. (2019a), Aly et al. (2020b), Chen et al. (2020a), Gao et al. (2020), Huang and Xu (2020a)
272 11-Allyl-cytisine S. secundiflora graphic file with name 12272_2021_1354_Figet_HTML.gif Wang et al. (2019a), Aly et al. (2020b), Chen et al. (2020a), Gao et al. (2020), Huang and Xu (2020a)
273 Anagyrine

S. chrysophylla

S. flavescens

S. franchetiana

S. korensis

S. secundiflora

S. tomentosa

S.tonkinensis

graphic file with name 12272_2021_1354_Figeu_HTML.gif

273: R = H

273′: R = OH

He et al. (2019), Wang et al. (2019a), Aly et al. (2020b), Cao and He (2020), Gao et al. (2020), Zhang et al. (2020a)
274 Lupanine

S. flavescens

S. japonica

S. korensis

S. secundiflora

S. subprostrata

graphic file with name 12272_2021_1354_Figev_HTML.gif

274: R = O

Aly et al. (2019, 2020a), Wang et al. (2019a), Cao and He (2020), Elberry et al. (2020), Gao et al. (2020), Guo et al. (2020), Zhang et al. (2020a)
275 Sparteine S. secundiflora 275: R = H2 Aly et al. (2019, 2020a), Wang et al. (2019a)
276 5,6-Dehydrolupanine

S. chrysophylla

S. korensis

S. secundiflora

graphic file with name 12272_2021_1354_Figew_HTML.gif Aly et al. (2019, 2020a), Wang et al. (2019a), Cao and He (2020)
277 Mamanine

S. chrysophylla

S. flavescens

graphic file with name 12272_2021_1354_Figex_HTML.gif Wang et al. (2019a), Cao and He (2020), Gao et al. (2020)
278 Epilamprolobin S. tomentosa graphic file with name 12272_2021_1354_Figey_HTML.gif Wang et al. (2019a)
279 Sophaline A S. alopecuroides graphic file with name 12272_2021_1354_Figez_HTML.gif Zhang et al. (2018c)
280 Sophaline B S. alopecuroides graphic file with name 12272_2021_1354_Figfa_HTML.gif Zhang et al. (2018c)
281 Sophaline.C.(5R) Sophaline D (5S) S. alopecuroides graphic file with name 12272_2021_1354_Figfb_HTML.gif Zhang et al. (2018b)
282 Sophaline E S. alopecuroides graphic file with name 12272_2021_1354_Figfc_HTML.gif Zhang et al. (2018c)

283a

283b

Sophaline G (5-αH)

Sophaline H (5-βH)

S. alopecuroides graphic file with name 12272_2021_1354_Figfd_HTML.gif Zhang et al. (2018c)
284 Aloperine S. alopecuroides graphic file with name 12272_2021_1354_Figfe_HTML.gif Yin et al. (2018), Ye et al. (2020)
285 Alopecurine A S. flavescens graphic file with name 12272_2021_1354_Figff_HTML.gif Zhang et al. (2018b)
286 Alopecurine B S. flavescens graphic file with name 12272_2021_1354_Figfg_HTML.gif Zhang et al. (2018b)
287 Flavesine G S. flavescens graphic file with name 12272_2021_1354_Figfh_HTML.gif Zhang et al. (2018b)
288 Flavesine H S. flavescens graphic file with name 12272_2021_1354_Figfi_HTML.gif Zhang et al. (2018b)
289 Flavesine I S. flavescens graphic file with name 12272_2021_1354_Figfj_HTML.gif Zhang et al. (2018b)
290 Flavesine J S. flavescens graphic file with name 12272_2021_1354_Figfk_HTML.gif Zhang et al. (2018b)
291 8α-Hydroxysophocarpine S. viciifolia graphic file with name 12272_2021_1354_Figfl_HTML.gif Gao et al. (2020)
292 13β-Hydroxyoxymatrine S. viciifolia graphic file with name 12272_2021_1354_Figfm_HTML.gif Gao et al. (2020)
293 9α-Acetoxymatrine S. viciifolia graphic file with name 12272_2021_1354_Figfn_HTML.gif Gao et al. (2020)
294 14β-Hydroxylupanine S. viciifolia graphic file with name 12272_2021_1354_Figfo_HTML.gif Gao et al. (2020)
295 Alopecine A S. alopecuroides graphic file with name 12272_2021_1354_Figfp_HTML.gif Wang et al. (2020b, c)
296 Alopecine B S. alopecuroides graphic file with name 12272_2021_1354_Figfq_HTML.gif Wang et al. (2020b, c)
297 Alopecine C S. alopecuroides graphic file with name 12272_2021_1354_Figfr_HTML.gif Wang et al. (2020b, c)
298 Alopecine D S. alopecuroides graphic file with name 12272_2021_1354_Figfs_HTML.gif Wang et al. (2020b, c)
299 Alopecine E S. alopecuroides graphic file with name 12272_2021_1354_Figft_HTML.gif Wang et al. (2020b, c)
300 5α,14β-Dihydroxymatrine S. tonkinensis graphic file with name 12272_2021_1354_Figfu_HTML.gif He et al. (2019)
301 14β-Hydroxymatrine S. tonkinensis graphic file with name 12272_2021_1354_Figfv_HTML.gif He et al. (2019)
302 7β-Sophoramine S. tonkinensis graphic file with name 12272_2021_1354_Figfw_HTML.gif He et al. (2019)
303 (+)-5α-Hydroxyoxysophocarpine S. tonkinensis graphic file with name 12272_2021_1354_Figfx_HTML.gif Pan et al. (2015)
304 (-)-12β-Hydroxyoxysophocarpine S.tonkinensis graphic file with name 12272_2021_1354_Figfy_HTML.gif Pan et al. (2015)
305 (+)-5α-Hydroxylemannine S. tonkinensis graphic file with name 12272_2021_1354_Figfz_HTML.gif Pan et al. (2015)
306 13-Methoxyanagyrine S. secundiflora graphic file with name 12272_2021_1354_Figga_HTML.gif Aly et al. (2021)
307 Sophalode A S. alopecuroides graphic file with name 12272_2021_1354_Figgb_HTML.gif Li et al. (2021a, b)
308 Sophalode B graphic file with name 12272_2021_1354_Figgc_HTML.gif
309 Sophalode C graphic file with name 12272_2021_1354_Figgd_HTML.gif
310 Sophalode D graphic file with name 12272_2021_1354_Figge_HTML.gif
311 Sophalode E S. alopecuroides graphic file with name 12272_2021_1354_Figgf_HTML.gif Li et al. (2021a)
312 Sophalode F graphic file with name 12272_2021_1354_Figgg_HTML.gif
313 Sophalode G graphic file with name 12272_2021_1354_Figgh_HTML.gif
314 Sophalode H S. alopecuroides graphic file with name 12272_2021_1354_Figgi_HTML.gif Li et al. (2021a)
315 Sophalode I graphic file with name 12272_2021_1354_Figgj_HTML.gif
316 Neosophoramine graphic file with name 12272_2021_1354_Figgk_HTML.gif
317 Sophalode J S. alopecuroides graphic file with name 12272_2021_1354_Figgl_HTML.gif Li et al. (2021a)
318 Sophalode K graphic file with name 12272_2021_1354_Figgm_HTML.gif
319 Sophalode L graphic file with name 12272_2021_1354_Figgn_HTML.gif