Fig. 5.

Important Polymorphisms in the AHR open reading frame: Top: Generalized domain identifiers for the AHR as mapped by multiple laboratories (see text). Middle: Structure of a generic AHR open reading frame from human. Bottom: Known results of common nonsynonymous SNPs of potential functional importance that found in human mouse and rat. Dark blue stars denote nonsynonymous SNPS. Open star represents a more rare nonsynonymous SNP that has been studied in vitro. Red star represents a stop codon (nonsense) that results in alterations in receptor molecular weight in commonly used mouse strains. Red arrow represents the position of a splice site variant in the rat intron between exons 10 and 11, resulting in multiple splice variants and three distinct molecular sizes of AHR in rat models.