Anatomical characteristics of articular cartilage in normal knee [33,39]. (A) Gradient structure and material components in articular cartilage. (B) Average thickness of cartilage, pressure distribution, and correlation of two factors in loading condition of human knee. The map showed the thickness of the local cartilage was correlated with its local pressure. Reproduced with permission [33,39]. Copyright 2015, Mary Ann Liebert, Inc; Copyright 2017, Public Library of Science.