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. 2021 Dec 8;8:1579–1596. doi: 10.2147/JHC.S327339

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© 2021 Aydin et al.

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Characterization of circulating exosomes among non-cirrhotics and cirrhotics with and without hepatocellular carcinoma (HCC). (A) Representative nanoparticle tracking analysis (NTA) images and distribution plots from exosomes isolated from the serum. Size distribution profile of exosomes with mean and mode of the population diameter ± standard error. (B) Serum exosome concentrations determined by NTA (n=25 per sample group). Data indicate mean ± standard deviation (SD) and analyzed by Student`s t-test. P values were displayed as ^nsP > 0.05, *P < 0.05, ***P < 0.001. (C) The size distribution of isolated exosomes among sample groups. The results are expressed as the mean ± SD and analyzed by Student`s t-test. (D) The concentration of exosome-derived CD63 (eCD63). Data indicate mean ± standard error of mean and analyzed by Student`s t-test. P values were displayed as ^nsP > 0.05, *P< 0.05, ***P < 0.001. (E) Receiver operating characteristic (ROC) curves for eCD63 in distinguishing HCC from non-cirrhotic controls (solid blue), HCC from cirrhosis alone (dashed green), and cirrhosis from non-cirrhotic controls (solid red).