Table 1.

Inclusion and exclusion criteria.

Inclusion criteria	Exclusion criteria
1. Age of at least 18 years	1. Conscious patient (GCS score of at least 8)
2. Out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause	2. Female of child-bearing potential, unless a negative human chorionic gonadotropin (hCG) test can rule out pregnancy within the inclusion window
3. Sustained return of spontaneous circulation (ROSC), defined as ROSC when chest compressions have not been required for 20 consecutive minutes and signs of circulation persist	3. In-hospital cardiac arrest (IHCA)
4. Unconsciousness (Glasgow Coma Scale (GCS) score of less than 8) after sustained ROSC	4. OHCA of presumed non-cardiac cause, such as after trauma, dissection/rupture of major artery or arrest caused by hypoxia (i.e., drowning, hanging, etc.)
5. Target temperature management (TTM) is indicated.	5. Known bleeding diathesis (medically induced coagulopathy does not exclude patient)
	6. Suspected or confirmed acute intracranial bleeding
	7. Suspected or confirmed acute ischemic stroke
	8. Unwitnessed asystole
	9. Known limitations in therapy and do-not-resuscitate order
	10. Known disease making 180-day survival unlikely
	11. Known pre-arrest cerebral performance category (CPC) score of 3 or 4
	12. More than 4 h (240 min) from ROSC to randomization
	13. Systolic blood pressure of less than 80 mm Hg in spite of fluid loading/vasopressor and/or inotropic medication and/or mechanical circulatory support*
	14. Temperature of less than 30 °C on admission
	15. Uncorrected blood glucose of less than 2.5 mmol/L at admission

^*If systolic blood pressure is recovering during the inclusion window the patient can be included.