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. 2021 Dec 1;12:732135. doi: 10.3389/fimmu.2021.732135

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Copyright © 2021 Heipertz, Zynda, Stav-Noraas, Hungler, Boucher, Kaur and Vemuri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic and functional properties of immature (left) and mature (right) NK cells. Immature NK cells express CD56^bright, absent, or CD16^dim, low KIR, and CD27 and are also known as NK^regulatory that exhibit low cytotoxicity, but high cytokine production. Mature NK cells, in contrast, express CD56^dim, high CD16, high KIRs, and CD57 and are also knows as NK^cytotoxic that exhibit high cytotoxicity and low cytokine production.