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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Bone. 2021 Oct 5;154:116228. doi: 10.1016/j.bone.2021.116228

Figure 1:

Figure 1:

Biochemical parameters reveal interactions between aging and CKD. A Schematic of study design (n=6–8 per group). B Both adenine-fed groups (AD) had lower endpoint body weight (p<0.0001) compared to control (Con) with an effect of age (p=0.002) and an age-by-disease interaction (p<0.0001). C Serum phosphorus was highest in adenine-fed groups (p<0.0001), although there was no age-by-disease interaction effect. D There were no differences in serum calcium across groups. E Blood urea nitrogen (BUN) was highest in aging AD mice (p=0.02) with an effect of disease (p<0.0001) and an age-by-disease interaction (p<0.0001). F Parathyroid hormone (PTH) was highest in aging AD mice (p=0.002) with an effect of disease (p<0.0001) and an interaction effect (p<0.0001). Data are presented as mean ± standard deviation. Bars with different letter notations are statistically different from each other (p<0.05).