TABLE 1:

GENE SETS USED

Description	Number of Genes	Genes
Osteoporosis genes, from literature review.	184	‘WNT3A, CYP17, TNFSF11, SOST, HDAC5, FKBP10, TGFB1, ITGA1, FOXL1, BMND, RANK, CATK, ITGB3, CALCR, VDR, REL, ADAMTS18, SOX6, COL, SPTBN1, SOX5, IL6, SOST, TMEM38B, SFRP4, DPYD, TYROBP, TUBA1B, CCNE1, TCIRG1, STARD3NL, RIL, FOXC2, P3H1, MARK3, TGFB3, MEF2C, LRP4, PLS3, FAM3C, PDGFD, IFITM5, OSTM1, MTHFR, CTNNB1, CSTA, CLCN7, MHC, SP7, SEC24D, MEPE, SERPINF1, TNFRSF11A, TNFRSF11B, RANKL, DCDC5, DCDC1, OPN, LEPRE, BMP2, BMP1, LRP5, WNT1, ESR1, DKK1, ZBTB40, CTR9, OPG, SPP1, SERPINH1, CRHR1, FLJ42280, PPIB, GPR177, CRTAP, RIZ1, OCIL, TIMP2, ERb, WNT10b, ER-a, CALM1, PRL, WNT10B, ARHGEF3, VEGF, PIR, WNT7b, IL-6, MDR1, LHB, ALOX5, DMP1, ENPP1, LRP1, NR1I3, FGFR2, ROR2, FGFR1, BMP7, IL-15, RUNX2, NPY, DBP, WNT7B, NFATC1, TNFRII, CYP19, Runx2, HOXA, TSHR, PTN, PTH, IL-23, WISP3, ANXA6, THSD7, THSD4, IGFBP2, MSTN, CNR2, APC, P2X 7, PPAR-g, TNFRSF1B, CYP19A1, SHBG, FLNB, FLNB FLT1, GHRH, CTR, IL-23R, FABP3, ADCY10, TGF-b1, FLT1, WNT3a, FZD1, THSD7A, CYP1B1, FZD6, Smad6, PTHRLH, SPARC, TNF-a, CASR, SRD5A2, HMGA2, COMT, LEPR, SFRP2, SFRP1, LRP6, P2X7, ALOX15, PLOD, SREBF1, COL1A2, COL1A1, NOG, CAR, PTHR2, PTHR1, CYP17A1, BMPR1B, GR, TWIST1, PTHLH, GDF5, HSD11B1, NOS3, ESRRA, LTBP2, LHCGR, CD40, CA10, AR, IL6R, PBX1, CA8, DKK2, MMP2, IL-6R, ALPL
Any bone-related genes, from literature reviews and scraping OMIM.	305	ABCC9, ACAN, ACVR1, ADAMTS2, ADAMTSL2, AGC1, AGXT, ALDH18A1, ALPL, AMER1, ANKH, ANO5, ANTXR2, AP2S1, APC, ARMC5, ASPN, ASXL2, ATL1, ATL3, ATP6V0A2, ATP7A, ATP7B, B3GALT6, B3GAT3, B4GALT7, BANF1, BDMR, BMND7, BMND8, BMP1, BMP2, BRAF, C1S, CA2, CALCR, CANT1, CASR, CAVIN1, CBS, CCT5, CHEK2, CHST14, CLCN5, CLCN7, COL10A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL5A1, COL5A2, COL9A1, COL9A2, COL9A3, COMP, COX4I2, CREB3L1, CRIPT, CRTAP, CTC1, CTSC, CTSK, CYBA, CYBB, CYP27A1, DCHS1, DDX58, DGKZ, DHCR24, DKC1, DNMT1, DSPP, DUSP6, DVL, DVL1, EED, EIF2AK3, ERCC6, ESR1, FAM111A, FAM123B, FAM134B, FAM20A, FAM20C, FAT4, FBN2, FERMT3, FGF17, FGF23, FGFR1, FGFR3, FKBP10, FKBP14, FLNA, FLNB, FLRT3, FRZB, FWS, G6PC, G6PT1, GALNS, GBA, GCM2, GLB1, GLIS3, GNAS, GNAS-AS1, GNAS1, GNASAS, GNPAT, GNPTAB, GORAB, GZF1, HECW2, HFE, HLA-DQA1, HLA-DQB1, HNRNPA1, HPGD, HRAS, HS6ST1, HSD17B4, HSPG2, IARS2, ICK, IER3IP1, IFIH1, IFITM5, IFT122, IGF1, IL17RD, IL1RN, IRX5, KCNJ1, KISS1R, KRAS, LBR, LEMD3, LEPRE1, LIFR, LMNA, LRP4, LRP5, LRP6, MAFB, MALT1, MAP2K1, MAP2K2, MAPRE2, MATN3, MET, MGAT2, MIFT, MIR2861, MITF, MMP13, MMP2, MPV17, MTAP, NAGA, NCF1, NCF2, NDN, NGF, NGFB, NOLA3, NOP10, NOTCH2, NPR2, NRAS, NSMF, NTRK1, OCRL, OCRL1, OI16, ORC1, OSTM1, P3H1, P4HB, PAPSS2, PCCA, PCCB, PCNT, PCNT2, PDB4, PDE11A, PDGFRB, PDLIM4, PEX12, PEX2, PHEX, PIGT, PIGY, PLOD, PLOD1, PLOD2, PLOD3, PLS3, PMM2, POF1B, POLD1, PORCN, PPIB, PPNAD4, PRKACA, PRKAR1A, PROK2, PRS, PSMB8, PTDSS1, PTH1R, PTHR1, PTRF, PYCR1, RAB3GAP1, RAB7A, RB1, RCHTS, RECQL2, RECQL4, RETREG1, RIN2, RNF125, RNU4ATAC, RPL11, RPS19, RSPRY1, RUNX2, SC5D, SC5DL, SEC23A, SEC24D, SEDL, SERPINH1, SFRP4, SH3BP2, SH3PXD2B, SHOX, SKI, SLC12A1, SLC17A5, SLC26A2, SLC34A1, SLC37A4, SLC39A13, SLC39A8, SLC40A1, SLC7A7, SLC9A3R1, SLCO2A1, SMAD3, SMAD4, SMARCAL1, SMARCD2, SMPD1, SMS, SNRPN, SNX10, SOST, SP7, SPARC, SPDT, SPRY4, SPTLC1, SPTLC2, SQSTM1, SRC, STAT1, STN1, STX16, TAPT1, TBC1D24, TBCE, TCBE, TCIRG1, TERT, TGFB3, TGFBR2, TINF2, TMEM165, TNFRSF11A, TNFRSF11B, TNFSF11, TNXB, TP53, TRAPPC2, TREM2, TRMT10A, TRPS1, TRPV4, TYROBP, UFSP2, UROS, VDR, VPS53, WBS, WISP3, WNK1, WNT1, WRN, ZBTB20, ZMPSTE24, ZNF687
Adrenocortical, from scraping OMIM.	48	AAAS, ABCD1, AIRE, ARNT2, BCOR, CACNA1H, CDKN1C, CYP11B1, CYP11B1, CYP11B2, GK, EBP, GCCD3, GLI3, GNAS, GNAS1, HESX1, HPE1, HSD17B4, HSD3B2, HYLS1, ICK, KCNJ5, KIAA0196, LHX3, LHX4, LMNA, MCM4, MKS1, MRPS7, NFKB2, NR0B1, NSDHL, PEX5, PEX6, POMC, POR, PRKAR1A, PROP1, RBM28, SAMD9, SGPL1, SIX3, STEAP3, WASHC5, WNT3, WNT4, ZMPSTE24,